Synonyms: (S)-pregabalin | CI 1008 | Lyrica® | Nervalin® | PD 144723
pregabalin is an approved drug (FDA and EMA (2004))
Compound class:
Synthetic organic
Comment: Pregabalin is a gabapentinoid class anti-seizure medication. Chemically, it is a 3-isobutyl derivative of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), but it appears to function as a modulator of voltage-gated calcium channels, rather than a GABA receptor agonist.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: pregabalin |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
Like gabapentin, pregabalin likely acts, at least in part, via inhibition of the α2δ subunit (CACNA2D1, P54289) of the VGCC. Some evidence exists to support the hypothesis that compounds such as pregabalin and gabapentin don't actually block presynaptic calcium channels, but rather exert an inhibitory effect on the re-cycling of the channels from endosomal pools back to the plasma membrane via interaction with intracellular δ subunits [1]. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA) |