Synonyms: (R)-FTY720 methyl ether | (R)-FTY720-OMe
Compound class:
Synthetic organic
Comment: ROMe is a synthetic sphingosine analogue.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
Sphingosine kinase 2 (SK2) phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P) and also phopshorylates the synthetic sphingosine analogue FTY720 [4]. FTY720 phosphate acts as an immunosuppressant by inhibiting the normal activation of S1P receptors by S1P which would normally stimulate T-lymphocyte egress from the lymph nodes [3]. ROMe is another synthetic sphingosine analogue with potential immunosuppressant/antineoplastic action [2]. |