tocainide   Click here for help

GtoPdb Ligand ID: 7309

Synonyms: Tonocard® | W-36095
Approved drug
tocainide is an approved drug (FDA (1984))
Compound class: Synthetic organic
Comment: Tocainide is a lidocaine analog.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 58.61
Molecular weight 192.13
XLogP 1.45
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CC(C(=Nc1c(C)cccc1C)O)N
Isomeric SMILES CC(C(=Nc1c(C)cccc1C)O)N
InChI InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)
InChI Key BUJAGSGYPOAWEI-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Tocainide is used to treat serious cardiac arrhythmias. Use has been discontinued in the US, but other national approval agencies may continue marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug stabilises the cardiac membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. ChEMBL report that this drug acts by blocking sodium channel α subunits (genes SNC1A-SNC11A) are listed in this database in the Voltage-gated sodium channels section.