Synonyms: Avodart® | GG-745 | GI-198745
dutasteride is an approved drug (FDA (2001))
Compound class:
Synthetic organic
Comment: Dutasteride is a synthetic androstane steroid that acts as a 5α-reductase inhibitor. It inhibits conversion of testosterone to dihydrotestosterone (DHT). There are three 5α-reductase isozymes: SRD5A1, SRD5A2 and SRD5A3, all of which are inhibited by dutasteride [1-2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: dutasteride |
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No information available. |
Summary of Clinical Use |
Approved for the treatment of benign prostatic hyperplasia (BPH) symptoms. |
Mechanism Of Action and Pharmacodynamic Effects |
Dutasteride is a 5α-reductase inhibitor, blocking the enzymatic conversion of testosterone to dihydrotestosterone (DHT). |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com |