plevitrexed   Click here for help

GtoPdb Ligand ID: 8278

Synonyms: ZD 9331 | ZD-9331 | ZD9331
Compound class: Synthetic organic
Comment: Plevitrexed is an orally bioavailable, small molecule, antifolate quinazoline derivative inhibitor of thymidylate synthetase with potential antineoplastic activity [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 11
Topological polar surface area 169.85
Molecular weight 532.2
XLogP 5.07
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C#CCN(c1ccc(c(c1)F)C(=O)NC(C(=O)O)CCc1n[nH]nn1)Cc1cc2c(=O)nc([nH]c2cc1C)C
Isomeric SMILES C#CCN(c1ccc(c(c1)F)C(=O)N[C@H](C(=O)O)CCc1n[nH]nn1)Cc1cc2c(=O)nc([nH]c2cc1C)C
InChI InChI=1S/C26H25FN8O4/c1-4-9-35(13-16-11-19-22(10-14(16)2)28-15(3)29-25(19)37)17-5-6-18(20(27)12-17)24(36)30-21(26(38)39)7-8-23-31-33-34-32-23/h1,5-6,10-12,21H,7-9,13H2,2-3H3,(H,30,36)(H,38,39)(H,28,29,37)(H,31,32,33,34)/t21-/m0/s1
InChI Key IEJSCSAMMLUINT-NRFANRHFSA-N
No information available.
Summary of Clinical Use Click here for help
The FDA has granted plevitrexed orphan drug designation for the treatment of ovarian and gastric cancers. A single Phase 2 clinical trial (NCT00014690) assessing plevitrexed in epithelial ovarian, fallopian tube and peritoneal cancers has been completed.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibition of the enzymatic activity of thymidylate synthase reduces the synthesis of precursor pyrimidine nucleotides. This prevents the formation of DNA and RNA and subsequently results in cell death.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00014690 ZD9331 With or Without Topotecan in Treating Patients With Refractory or Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Phase 2 Interventional National Cancer Institute (NCI)