elagolix   Click here for help

GtoPdb Ligand ID: 8362

Synonyms: compound 10b [PMID 19006286] | NBI-56418 | NBI56418 | Orilissa®
Approved drug PDB Ligand
elagolix is an approved drug (FDA (2018))
Compound class: Synthetic organic
Comment: Elagolix is a non-peptide gonadotrophin receptor (GnRHR) antagonist [1]. As of July 2018, it is the first and only FDA-approved oral GnRH antagonist available for the treatment of moderate to severe endometriosis pain.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 102.56
Molecular weight 631.21
XLogP 7.35
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1cccc(c1F)c1c(=O)n(CC(c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F
Isomeric SMILES COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F
InChI InChI=1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/t25-/m0/s1
InChI Key HEAUOKZIVMZVQL-VWLOTQADSA-N
No information available.
Summary of Clinical Use Click here for help
Elagolix is an approved monotherapy for the management of moderate to severe pain that is associated with endometriosis. Approval was granted by the FDA in May 2020, for the elagolix-containing medication Oriahnn® to be used for non-surgical management of heavy menstrual bleeding associated with uterine fibroids in pre-menopausal women. The Oriahnn® treatment regimen is 2 capsules/day, one taken in the morning (containing elagolix + estradiol + norethindrone acetate) and the other taken in the evening (elagolix only), for a maximum of 24 months.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As a GnRHR antagonist, elegolix will act to suppress the pituitary-gonadal axis, leading to decreased levels of gonadal sex hormones. This is of clinical benefit in hormone-sensitive diseases such as endometriosis.