1R-11   Click here for help

GtoPdb Ligand ID: 10138

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: 1R-11 is a synthetic lipoxin mimetic that exhibits anti-inflammatory activities via a mechanism which appears to be mediated by agonism of the ALX/FPR2 G protein-coupled receptor [1].
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 104.81
Molecular weight 382.25
XLogP 2.42
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CCCCCC(c1c(C=CC(C(CCCC(=O)OC)O)O)nc(n1C)C)O
Isomeric SMILES CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O
InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18+/m0/s1
InChI Key PLBGFBROZZUTKG-PHCFSIKCSA-N
Immunopharmacology Comments
Lipoxins are endogenous eicosanoids that are involved in the attenuation of inflammation. Lipoxin mimetics are therefore of pharmaceutical interest as potential non-steroidal anti-inflammatory agents. Compound 1R-11 is one such mimetic that has potent anti-inflammatory effects in vitro and in vivo. These effects are dependent on 1R-11-mediated agonist action at the ALX/FPR2 receptor [1]. 1R-11 inhibits NFκB activation (IC50 1 nM in a luciferase reporter assay) and production of pro-inflammatory mediators (nM IC50 values in brackets): IFNγ (4.4), IL-6 (76.6) and IL-12p70 (5.1) [1].