Synonyms: ALKS-8700 | ALKS8700 | BIIB098 | Vumerity®
diroximel fumarate is an approved drug (FDA (2019), EMA (2021))
Compound class:
Synthetic organic
Comment: Diroximel fumarate is a novel oral fumarate prodrug. It is rapidly converted to monomethyl fumarate, which is the same active metabolite of dimethyl fumarate.
|
|
Immunopharmacology Comments |
Diroximel fumarate is converted to an active metabolite that is an inhibitor of the KEAP1-Nrf2 protein-protein interaction, or functional Nrf2 activator. Compounds exhibiting this mechanism of action have anti-inflammatory and cytoprotective activity. |