Immunopharmacology Comments

IL-1Ra is an IL-1 family cytokine. It is a functional antagonist for IL-1α and IL-1β.

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Deficiency of IL-1 receptor antagonist	OMIM: 612852 Orphanet: ORPHA210115	DIRA is caused by mutations in the IL1RN gene that cause loss of function of IL-1RA protein. The condition is responsive to IL-1 blocking therapies such as anakinra, rilonacept, and canakinumab.	1-2
Rheumatoid arthritis	Disease Ontology: DOID:7148 OMIM: 180300	A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug called Anakinra