Compound class:
Antibody
Comment: MAB92 is an IL-36 receptor antagonistic antibody that mimics the action of IL-36RA cytokine [1]. It is selective for the human IL-36 receptor. A related construct with overlapping epitope binding and function, MAB04, is mouse cross-reactive and is suitable for in vivo pharmacology studies [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| MAB92 is an IL-36RA mimmetic that shows potential as a novel therapy for epithelial cell-mediated inflammation caused by genetic IL-36RA deficiency [1]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Deficiency of IL-36R antagonist |
OMIM:
614204 Orphanet: ORPHA404546 |
MAB92 is an experimental antibody with activity against DITRA type cutaneous pustulitis. | |
