Synonyms: AZD-3241 | AZD3241
Compound class:
Synthetic organic
Comment: Verdiperstat is a thiouracil-based, irreversible mechanism-based, investigational myeloperoxidase (MPO) inhibitor [2]. It was designed to delay progression in patients with neurodegenerative brain disorders.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. AstraZeneca.
AZD3241. Accessed on 20/08/2018. Modified on 20/08/2018. ncats.nih.gov, https://ncats.nih.gov/files/AZD3241-2016.pdf |
2. Johnström P, Bergman L, Varnäs K, Malmquist J, Halldin C, Farde L. (2015)
Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol, 42 (6): 555-60. [PMID:25726760] |
3. Jucaite A, Svenningsson P, Rinne JO, Cselényi Z, Varnäs K, Johnström P, Amini N, Kirjavainen A, Helin S, Minkwitz M et al.. (2015)
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain, 138 (Pt 9): 2687-700. [PMID:26137956] |
4. Kaindlstorfer C, Sommer P, Georgievska B, Mather RJ, Kugler AR, Poewe W, Wenning GK, Stefanova N. (2015)
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotox Res, 28 (3): 185-94. [PMID:26194617] |