Synonyms: DE-117 (omidenepag isopropyl ophthalmic solution) | Omlonti® | UR-7276 | UR7276
omidenepag is an approved drug (FDA (2022))
Compound class:
Synthetic organic
Comment: Omidenepag acts as a selective agonist of the prostanoid EP2 receptor [5]. It is administered as an opthalmic solution containing omidenepag isopropyl (which is named DE-117) in clinical studies [4,6]. Omidenepag isopropyl has PubChem CID 44230999.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Aihara M, Lu F, Kawata H, Iwata A, Odani-Kawabata N. (2021)
Twelve-month efficacy and safety of omidenepag isopropyl, a selective EP2 agonist, in open-angle glaucoma and ocular hypertension: the RENGE study. Jpn J Ophthalmol, 65 (6): 810-819. [PMID:34495425] |
2. Aihara M, Lu F, Kawata H, Iwata A, Odani-Kawabata N, Shams NK. (2020)
Omidenepag Isopropyl Versus Latanoprost in Primary Open-Angle Glaucoma and Ocular Hypertension: The Phase 3 AYAME Study. Am J Ophthalmol, 220: 53-63. [PMID:32533949] |
3. Aihara M, Ropo A, Lu F, Kawata H, Iwata A, Odani-Kawabata N, Shams N. (2020)
Intraocular pressure-lowering effect of omidenepag isopropyl in latanoprost non-/low-responder patients with primary open-angle glaucoma or ocular hypertension: the FUJI study. Jpn J Ophthalmol, 64 (4): 398-406. [PMID:32572719] |
4. Kaplan TM, Sit AJ. (2022)
Emerging drugs for the treatment of glaucoma: a review of phase II & III trials. Expert Opin Emerg Drugs, 27 (3): 321-331. [PMID:35924872] |
5. Kirihara T, Taniguchi T, Yamamura K, Iwamura R, Yoneda K, Odani-Kawabata N, Shimazaki A, Matsugi T, Shams N, Zhang JZ. (2018)
Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci, 59 (1): 145-153. [PMID:29332128] |
6. Matsuo M, Matsuoka Y, Tanito M. (2022)
Efficacy and Patient Tolerability of Omidenepag Isopropyl in the Treatment of Glaucoma and Ocular Hypertension. Clin Ophthalmol, 16: 1261-1279. [PMID:35510270] |