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Synonyms: WRW4
Compound class:
Peptide or derivative
Comment: Selective FPR2 antagonist peptide.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Bae YS, Lee HY, Jo EJ, Kim JI, Kang HK, Ye RD, Kwak JY, Ryu SH. (2004)
Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol, 173 (1): 607-14. [PMID:15210823] |
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2. Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R. (2013)
Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways. Pharmacol Ther, 140 (3): 280-9. [PMID:23880288] |
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3. Shin EH, Lee HY, Kim SD, Jo SH, Kim MK, Park KS, Lee H, Bae YS. (2006)
Trp-Arg-Trp-Trp-Trp-Trp antagonizes formyl peptide receptor like 2-mediated signaling. Biochem Biophys Res Commun, 341 (4): 1317-22. [PMID:16476585] |
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4. Stama ML, Lacivita E, Kirpotina LN, Niso M, Perrone R, Schepetkin IA, Quinn MT, Leopoldo M. (2017)
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress. ChemMedChem, 12 (22): 1839-1847. [PMID:28922577] |
