RSLV-132   Click here for help

GtoPdb Ligand ID: 10412

Synonyms: RSLV132
Immunopharmacology Ligand
Comment: RSLV-132 is a fully human biologic fusion protein that is comprised of human RNase fused to the Fc domain of human IgG1 [1]. The peptide sequence of RSLV-132 has not yet been formally disclosed.
References
1. Burge DJ, Eisenman J, Byrnes-Blake K, Smolak P, Lau K, Cohen SB, Kivitz AJ, Levin R, Martin RW, Sherrer Y et al.. (2017)
Safety, pharmacokinetics, and pharmacodynamics of RSLV-132, an RNase-Fc fusion protein in systemic lupus erythematosus: a randomized, double-blind, placebo-controlled study.
Lupus, 26 (8): 825-834. [PMID:27852935]
2. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. (2002)
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.
Nature, 416 (6881): 603-7. [PMID:11948342]
3. Lövgren T, Eloranta ML, Båve U, Alm GV, Rönnblom L. (2004)
Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
Arthritis Rheum, 50 (6): 1861-72. [PMID:15188363]
4. Posada J, Valadkhan S, Burge D, Davies K, Tarn J, Casement J, Jobling K, Gallagher P, Wilson D, Barone F et al.. (2021)
Improvement of Severe Fatigue Following Nuclease Therapy in Patients With Primary Sjögren's Syndrome: A Randomized Clinical Trial.
Arthritis Rheumatol, 73 (1): 143-150. [PMID:32798283]