Synonyms: ALKS-8700 | ALKS8700 | BIIB098 | Vumerity®
diroximel fumarate is an approved drug (FDA (2019), EMA (2021))
Compound class:
Synthetic organic
Comment: Diroximel fumarate is a novel oral fumarate prodrug. It is rapidly converted to monomethyl fumarate, which is the same active metabolite of dimethyl fumarate.
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References |
1. Palte MJ, Wehr A, Tawa M, Perkin K, Leigh-Pemberton R, Hanna J, Miller C, Penner N. (2019)
Improving the Gastrointestinal Tolerability of Fumaric Acid Esters: Early Findings on Gastrointestinal Events with Diroximel Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis from the Phase 3, Open-Label EVOLVE-MS-1 Study. Adv Ther, 36 (11): 3154-3165. [PMID:31538304] |