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Synonyms: Adakveo® | crizanlizumab-tmca | hSel001 [2] | SEG101
crizanlizumab is an approved drug (FDA (2019), EMA (2020))
Compound class:
Antibody
Comment: Crizanlizumab is a humanized anti-P-selectin monoclonal that was developed by Selexys Pharmaceuticals (and later acquired by Novartis) as a preventative therapy for sickle cell crises [1]. The antibody and its use are claimed in Selexys' patent WO2012088265A1 [2]. Crizanlizumab was designed to limit complement activation. In clinical trial no anti-crizanlizumab antibodies could be detected [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Ataga KI, Kutlar A, Kanter J, Liles D, Cancado R, Friedrisch J, Guthrie TH, Knight-Madden J, Alvarez OA, Gordeuk VR et al.. (2017)
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease. N Engl J Med, 376 (5): 429-439. [PMID:27959701] |
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2. Rollins S, ALvarez R, Rother R, Kawar ZS, Mcever RP. (2012)
Anti-p-selectin antibodies and methods of their use and identification. Patent number: WO2012088265A1. Assignee: Selexys Pharmaceuticals Corporation. Priority date: 21/12/2010. Publication date: 28/06/2012. |
