Synonyms: SK&F 59962
Compound class:
Synthetic organic
Comment: Cefazaflur (SK&F 59962) is a semisynthetic first generation cephalosporin antibacterial [1]. It did not progress beyond preclinical development. Cefazaflur binds to and inactivates penicillin-binding proteins (PBPs) and thereby disrupts normal bacterial cell wall assembly.
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References |
1. Counts GW, Gregory D, Zeleznik D, Turch M. (1977)
Cefazaflur, a new parenteral cephalosporin: in vitro studies. Antimicrob Agents Chemother, 11 (4): 708-11. [PMID:324399] |
2. DeMarinis RM, Hoover JR, Lam LL, Uri JV, Guarini JR, Phillips L, Actor P, Weisbach JA. (1976)
Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-sulfonylacetamido-3-cephem-4-carboxylic acids. J Med Chem, 19 (6): 754-9. [PMID:781242] |