Synonyms: ACX-362E | ACX362E
Compound class:
Synthetic organic
Comment: Ibezapolstat is a clinical stage bacterial DNA polymerase IIIC inhibitor that is in development as a novel therapeutic against C. difficile infection [2-3].
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References |
1. Garey KW, McPherson J, Dinh AQ, Hu C, Jo J, Wang W, Lancaster CK, Gonzales-Luna AJ, Loveall C, Begum K et al.. (2022)
Efficacy, Safety, Pharmacokinetics, and Microbiome Changes of Ibezapolstat in Adults with Clostridioides difficile Infection: A Phase 2a Multicenter Clinical Trial. Clin Infect Dis, 75 (7): 1164-1170. [PMID:35134880] |
2. Murray B, Wolfe C, Marra A, Pillar C, Shinabarger D. (2020)
In vitro activity of the novel antibacterial agent ibezapolstat (ACX-362E) against Clostridioides difficile. J Antimicrob Chemother, 75 (8): 2149-2155. [PMID:32285102] |
3. van Eijk E, Boekhoud IM, Kuijper EJ, Bos-Sanders IMJG, Wright G, Smits WK. (2019)
Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile. Antimicrob Agents Chemother, 63 (2). DOI: 10.1128/AAC.01363-18 [PMID:30455241] |