leinamycin   Click here for help

GtoPdb Ligand ID: 11041

Synonyms: DC-107 | DC107
Compound class: Natural product or derivative
Comment: Leinamycin is a macrolactam antibacterial (activity against Gram-positive and gram-negative bacteria) that also has potent anti-tumour activity [1,3-4]. It is produced by several species of Streptomyces atroolivaceus. Cytotoxicity against cancer cells hinges upon the compound's 1,3-dioxo-1,2-dithiolane moiety [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 206.41
Molecular weight 510.1
XLogP -1.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C/C/1=C\[C@@H](O)C(=O)/C=C/C=C\c2nc([C@H](NC(=O)C[C@@]3(CC1)S(=O)SC(=O)[C@]3(C)O)C)sc2
Isomeric SMILES C/C/1=C\[C@@H](O)C(=O)/C=C/C=C\c2nc([C@H](NC(=O)C[C@@]3(CC1)S(=O)SC(=O)[C@]3(C)O)C)sc2
InChI InChI=1S/C22H26N2O6S3/c1-13-8-9-22(21(3,29)20(28)32-33(22)30)11-18(27)23-14(2)19-24-15(12-31-19)6-4-5-7-16(25)17(26)10-13/h4-7,10,12,14,17,26,29H,8-9,11H2,1-3H3,(H,23,27)/b6-4-,7-5+,13-10+/t14-,17-,21+,22-,33?/m1/s1
InChI Key ZHTRILQJTPJGNK-FYBAATNNSA-N
References
1. Hara M, Asano K, Kawamoto I, Takiguchi T, Katsumata S, Takahashi K, Nakano H. (1989)
Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
J Antibiot, 42 (12): 1768-74. [PMID:2621160]
2. Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B. (2015)
Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
Bioorg Med Chem Lett, 25 (21): 4899-4902. [PMID:26071634]
3. Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y et al.. (2017)
Discovery of the leinamycin family of natural products by mining actinobacterial genomes.
Proc Natl Acad Sci USA, 114 (52): E11131-E11140. [PMID:29229819]
4. Viswesh V, Hays AM, Gates K, Sun D. (2012)
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
Bioorg Med Chem, 20 (14): 4413-21. [PMID:22682923]