Synonyms: BRL-1621 | BRL1621 | chloroxacillin | Methocillin S | Syntarpen® | Tegopen®
cloxacillin is an approved drug (FDA (1971))
Compound class:
Synthetic organic
Comment: Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibacterial [1-2]. It has less potent antibacterial activity than benzylpenicillin.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. KNOX R, MACLAREN DM, SMITH JT, TRAFFORD JA, BARNES RD. (1962)
BRL 1621: a comparison with other isoxazolyl penicillins. Br Med J, 2 (5308): 831-2. [PMID:14457373] |
2. KNUDSEN ET, BROWN DM, ROLINSON GN. (1962)
A new orally effective penicllinase-stable penicillin--BRL. 1621. Lancet, 2 (7257): 632-4. [PMID:14033875] |
3. Lemaire S, Olivier A, Van Bambeke F, Tulkens PM, Appelbaum PC, Glupczynski Y. (2008)
Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics. Antimicrob Agents Chemother, 52 (8): 2797-805. [PMID:18519727] |