Synonyms: trans‐4‐butylcyclohexane carboxylic acid
Compound class:
Synthetic organic
Comment: X-ray crystallography shows that 4‐BCCA inhibits AMPA receptor activity by binding (with low‐affinity) to a region in the receptor's transmembrane domain (PDB ID 6XSR) [1]. The interaction was confirmed by mutagenesis of the amino acids predicted to be involved in the ligand-receptor interaction by the X-ray structure and electropysiological measurements in vitro. This discovery helps to explain the molecular mechanism underlying 4‐BCCA's anti-epileptic activity.
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References |
1. Yelshanskaya MV, Singh AK, Narangoda C, Williams RSB, Kurnikova MG, Sobolevsky AI. (2022)
Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid. Br J Pharmacol, 179 (14): 3628-3644. [PMID:32959886] |