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Compound class:
Peptide or derivative
Comment: This is a synthetic, modified analogue of the endogenous galanin receptor 2/3 peptide ligand spexin-1[1-2]. It selectively activates signalling via GAL2 and is inactive at the GAL3 receptor [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Lee YN, Reyes-Alcaraz A, Yun S, Lee CS, Hwang JI, Seong JY. (2020)
Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors. PLoS One, 15 (3): e0230872. [PMID:32231393] |
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2. Reyes-Alcaraz A, Lee YN, Son GH, Kim NH, Kim DK, Yun S, Kim DH, Hwang JI, Seong JY. (2016)
Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice. Sci Rep, 6: 21453. [PMID:26907960] |
