Synonyms: GS621763
Compound class:
Synthetic organic
Comment: GS-621763 is an orally bioavailable triester prodrug of remdesivir (GS-5734) [1]. It is metabolised into the same active nucleoside triphosphate as remdesivir. Like its parent, this prodrug results in inhibition of viral RNA-dependent RNA polymerase (RdRP), and it has been evaluated against SARS-CoV-2 RdRP. GS-621763 has antiviral activity in vitro (in human primary cell systems) and has demonstrated in vivo therapeutic efficacy in mice infected with SARS-CoV-2.
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References |
1. Schäfer A, Martinez DR, Won JJ, Moreira FR, Brown AJ, Gully KL, Kalla R, Chun K, Du Pont V, Babusis D et al.. (2021)
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv, Preprint. DOI: 10.1101/2021.09.13.460111 [PMID:34545367] |