relaxin   Click here for help

GtoPdb Ligand ID: 1989

Synonyms: H2 relaxin
Species: Human
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References
1. Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ. (2005)
Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).
J Pharmacol Exp Ther, 313 (2): 677-87. [PMID:15649866]
2. Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA. (2008)
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.
J Biol Chem, 283 (25): 17287-97. [PMID:18434306]
3. Kocan M, Sarwar M, Hossain MA, Wade JD, Summers RJ. (2014)
Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).
Br J Pharmacol, 171 (11): 2827-41. [PMID:24641548]
4. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ. (2002)
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.
J Biol Chem, 277 (35): 31283-6. [PMID:12114498]
5. Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jörnvall H, Sillard R, Lovenberg TW. (2003)
Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.
J Biol Chem, 278 (50): 50754-64. [PMID:14522968]
6. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ. (2003)
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.
J Biol Chem, 278 (10): 7855-62. [PMID:12506116]
7. van der Westhuizen ET, Christopoulos A, Sexton PM, Wade JD, Summers RJ. (2010)
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).
Mol Pharmacol, 77 (5): 759-72. [PMID:20159943]