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Synonyms: omega-Aga-IVA | Omega-agatoxin-Aa4a
Compound class:
Peptide or derivative
Comment: From the venom of Agelenopsis aperta (North American funnel-web spider)
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Bourinet E, Soong TW, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi GW, Nargeot J, Snutch TP. (1999)
Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci, 2 (5): 407-15. [PMID:10321243] |
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2. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP et al.. (2014)
International union of basic and clinical pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacol Rev, 66 (4): 918-47. [PMID:25026896] |
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3. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME. (1992)
P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature, 355 (6363): 827-9. [PMID:1311418] |
