phrixotoxin 2   Click here for help

GtoPdb Ligand ID: 2583

Synonyms: κ-theraphotoxin-Ps1b | κ-TRTX-Ps1b | PaTX 2 | PaTX2
Compound class: Peptide or derivative
Comment: From Paraphysa scrofa (Chilean copper tarantula)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Carrasquillo Y, Burkhalter A, Nerbonne JM. (2012)
A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.
J Physiol (Lond.), 590 (Pt 16): 3877-90. [PMID:22615428]
2. Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H. (2004)
Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus.
Protein Sci, 13 (5): 1197-208. [PMID:15096626]
3. Qu YJ, Bondarenko VE, Xie C, Wang S, Awayda MS, Strauss HC, Morales MJ. (2007)
W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition.
Am J Physiol Heart Circ Physiol, 292 (5): H2364-77. [PMID:17220193]
4. Wang H, Shi H, Zhang L, Pourrier M, Yang B, Nattel S, Wang Z. (2000)
Nicotine is a potent blocker of the cardiac A-type K(+) channels. Effects on cloned Kv4.3 channels and native transient outward current.
Circulation, 102 (10): 1165-71. [PMID:10973847]
5. Yeung SY, Ohya S, Sergeant GP, Pucovský V, Greenwood IA. (2006)
Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes.
Br J Pharmacol, 149 (6): 676-86. [PMID:17016508]