Synonyms: (Trp63-Trp64)-C3a-(63-77) | C3a receptor superagonist | EP141
Compound class:
Peptide or derivative
Comment: Synthetic analogue of C3a
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
References |
1. Ames RS, Tornetta MA, Foley JJ, Hugli TE, Sarau HM. (1997)
Evidence that the receptor for C4a is distinct from the C3a receptor. Immunopharmacology, 38 (1-2): 87-92. [PMID:9476119] |
2. Ember JA, Johansen NL, Hugli TE. (1991)
Designing synthetic superagonists of C3a anaphylatoxin. Biochemistry, 30 (15): 3603-12. [PMID:2015217] |
3. Scully CC, Blakeney JS, Singh R, Hoang HN, Abbenante G, Reid RC, Fairlie DP. (2010)
Selective hexapeptide agonists and antagonists for human complement C3a receptor. J Med Chem, 53 (13): 4938-48. [PMID:20527893] |