IL-25

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Ligands
IL-25 (Human)

GtoPdb Ligand ID: 5876

Synonyms: IL-17E | interleukin-17E | interleukin-25

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-25 shares sequence similarity with IL-17 family proteins, and shares the IL17RB cytokine receptor with IL-17B.

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

References
1. Benatar T, Cao MY, Lee Y, Lightfoot J, Feng N, Gu X, Lee V, Jin H, Wang M, Wright JA et al.. (2010) IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo. Cancer Immunol Immunother, 59 (6): 805-17. [PMID:20012860]
2. Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA et al.. (2006) Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med, 203 (4): 843-9. [PMID:16606667]

References

1. Benatar T, Cao MY, Lee Y, Lightfoot J, Feng N, Gu X, Lee V, Jin H, Wang M, Wright JA et al.. (2010)
IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo.
Cancer Immunol Immunother, 59 (6): 805-17. [PMID:20012860]

2. Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA et al.. (2006)
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.
J Exp Med, 203 (4): 843-9. [PMID:16606667]