Synonyms: AMYViD® | AV-45 | florbetapir (18F)
florbetapir is an approved drug (FDA (2012), EMA (2013))
Compound class:
Synthetic organic
Comment: Florbetapir F18 is a molecular imaging agent (diagnostic radiopharmaceutical) that binds to β-amyloid aggregates in Alzheimer's brains.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Cortes-Blanco A, Prieto-Yerro C, Martinez-Lazaro R, Zamora J, Jiménez-Huete A, Haberkamp M, Pohly J, Enzmann H, Zinserling J, Strassmann V et al.. (2014)
Florbetapir (18F) for brain amyloid positron emission tomography: highlights on the European marketing approval. Alzheimers Dement, 10 (5 Suppl): S395-9. [PMID:24418060] |
2. Yu P, Cui M, Wang X, Zhang X, Li Z, Yang Y, Jia J, Zhang J, Ono M, Saji H et al.. (2012)
¹⁸F-labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. Eur J Med Chem, 57: 51-8. [PMID:23047223] |