sorbinil   Click here for help

GtoPdb Ligand ID: 7415

Synonyms: CP-45634
PDB Ligand
Compound class: Synthetic organic
Comment: Chemical structure is derived from [5]. Sorbinil is an experimental aldose reductase inhibitor.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 67.43
Molecular weight 236.06
XLogP 1
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Fc1cc2C3(CCOc2cc1)NC(=O)NC3=O
Isomeric SMILES Fc1cc2[C@]3(CCOc2cc1)NC(=O)NC3=O
InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChI Key LXANPKRCLVQAOG-NSHDSACASA-N
References
1. Greene DA, Lattimer SA. (1984)
Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity.
Diabetes, 33 (8): 712-6. [PMID:6086432]
2. Jaspan J, Maselli R, Herold K, Bartkus C. (1983)
Treatment of severely painful diabetic neuropathy with an aldose reductase inhibitor: relief of pain and improved somatic and autonomic nerve function.
Lancet, 2 (8353): 758-62. [PMID:6137601]
3. Maccari R, Del Corso A, Giglio M, Moschini R, Mura U, Ottanà R. (2011)
In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.
Bioorg Med Chem Lett, 21 (1): 200-3. [PMID:21129963]
4. Oka M, Matsumoto Y, Sugiyama S, Tsuruta N, Matsushima M. (2000)
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
J Med Chem, 43 (12): 2479-83. [PMID:10882376]
5. Sarges R, Bordner J, Dominy BW, Peterson MJ, Whipple EB. (1985)
Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.
J Med Chem, 28 (11): 1716-20. [PMID:3934383]
6. Srivastava SK, Ramana KV, Bhatnagar A. (2005)
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options.
Endocr Rev, 26 (3): 380-92. [PMID:15814847]
7. Young RJ, Ewing DJ, Clarke BF. (1983)
A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy.
Diabetes, 32 (10): 938-42. [PMID:6225686]