CCL4   Click here for help

GtoPdb Ligand ID: 757

Synonyms: HC21 | macrophage inflammatory protein-1β | MIP-1β
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL4 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1β or MIP-1β. It acts in a dimer with CCL3 (MIP-1α) [1].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. A-González N, Castrillo A. (2011)
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Biochim Biophys Acta, 1812 (8): 982-94. [PMID:21193033]
2. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG. (2001)
B cells and professional APCs recruit regulatory T cells via CCL4.
Nat Immunol, 2 (12): 1126-32. [PMID:11702067]
3. Chou CC, Fine JS, Pugliese-Sivo C, Gonsiorek W, Davies L, Deno G, Petro M, Schwarz M, Zavodny PJ, Hipkin RW. (2002)
Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL-60 cells: antagonism of hCCR1 activation by MIP-1beta.
Br J Pharmacol, 137 (5): 663-75. [PMID:12381680]
4. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. (1995)
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.
Science, 270 (5243): 1811-5. [PMID:8525373]
5. Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM. (1995)
Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.
J Biol Chem, 270: 29671-29675. [PMID:8530354]
6. Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M. (2005)
Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Biochem Pharmacol, 71 (1-2): 163-72. [PMID:16298345]
7. Ren M, Guo Q, Guo L, Lenz M, Qian F, Koenen RR, Xu H, Schilling AB, Weber C, Ye RD et al.. (2010)
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.
EMBO J, 29 (23): 3952-66. [PMID:20959807]
8. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell Immunol, 189 (2): 160-8. [PMID:9790730]
9. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A. (1988)
Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta.
J Exp Med, 168 (6): 2251-9. [PMID:3058856]