SB269652   Click here for help

GtoPdb Ligand ID: 7694

Synonyms: SB-269,652 | SB-269652
Compound class: Synthetic organic
Comment: SB269652 was originally described as an allosteric antagonist at dopamine D3 and D2 receptors [4]. Further analysis has revealed a novel mechanism of allostery, which relies on the presence of receptor dimers [2]. SB269652 acts as a bitopic ligand [3], with one pharmacophore binding to one receptor protomer and the other pharmacophore allosterically modulating the binding of a ligand on the second partner in the dimer, in this instance rendering the compound a negative allosteric regulator of dopamine binding to the D2 receptor [2].
PubChem CID 9910352 represents the compound structure without specified stereochemistry.
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Ligand Activity Visualisation Charts

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 71.92
Molecular weight 426.24
XLogP 4.57
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES N#Cc1ccc2c(c1)CN(CC2)CCC1CCC(CC1)NC(=O)c1cc2c([nH]1)cccc2
Isomeric SMILES N#Cc1ccc2c(c1)CN(CC2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1cc2c([nH]1)cccc2
InChI InChI=1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-
InChI Key JGLGOAQPUQITLD-OGAOHHHESA-N
References
1. Furman CA, Roof RA, Moritz AE, Miller BN, Doyle TB, Free RB, Banala AK, Paul NM, Kumar V, Sibley CD et al.. (2015)
Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists.
Eur Neuropsychopharmacol, 25 (9): 1448-61. [PMID:25583363]
2. Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B et al.. (2014)
A new mechanism of allostery in a G protein-coupled receptor dimer.
Nat Chem Biol, 10 (9): 745-52. [PMID:25108820]
3. Lane JR, Sexton PM, Christopoulos A. (2013)
Bridging the gap: bitopic ligands of G-protein-coupled receptors.
Trends Pharmacol Sci, 34 (1): 59-66. [PMID:23177916]
4. Silvano E, Millan MJ, Mannoury la Cour C, Han Y, Duan L, Griffin SA, Luedtke RR, Aloisi G, Rossi M, Zazzeroni F et al.. (2010)
The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors.
Mol Pharmacol, 78 (5): 925-34. [PMID:20702763]