Synonyms: BM 131258 | BM13.1258 | R 483
Compound class:
Synthetic organic
Comment: Edaglitazone is a potent and selective peroxisome proliferator-activated (PPARγ) receptor agonist [1-2].
The INN record for edaglitazone confirms a racemic mixture of stereoisomers. We show the structure without defined stereochemistry to represent the mixture. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Dietz M, Mohr P, Kuhn B, Maerki HP, Hartman P, Ruf A, Benz J, Grether U, Wright MB. (2012)
Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem, 7 (6): 1101-11. [PMID:22489042] |
2. Fürnsinn C, Brunmair B, Meyer M, Neschen S, Furtmüller R, Roden M, Kühnle HF, Nowotny P, Schneider B, Waldhäusl W. (1999)
Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br J Pharmacol, 128 (6): 1141-8. [PMID:10578125] |