telotristat ethyl   Click here for help

GtoPdb Ligand ID: 9490

Synonyms: LX-1606 | LX1606 | Xermelo®
Approved drug Immunopharmacology Ligand
telotristat ethyl is an approved drug (FDA (2017))
Compound class: Synthetic organic
Comment: Telotristat ethyl is an oral tryptophan hydroxylase inhibitor. Telotristat ethyl is the USAN, the INN is telotristat (represented in PubChem CID 25025298.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 130.65
Molecular weight 574.17
XLogP 6
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CCOC(=O)C(Cc1ccc(cc1)c1cc(nc(n1)N)OC(C(F)(F)F)c1ccc(cc1n1ccc(n1)C)Cl)N
Isomeric SMILES CCOC(=O)[C@H](Cc1ccc(cc1)c1cc(nc(n1)N)O[C@@H](C(F)(F)F)c1ccc(cc1n1ccc(n1)C)Cl)N
InChI InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1
InChI Key MDSQOJYHHZBZKA-GBXCKJPGSA-N
References
1. Bae EJ, Choi WG, Pagire HS, Pagire SH, Parameswaran S, Choi JH, Yoon J, Choi WI, Lee JH, Song JS et al.. (2021)
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.
J Med Chem, 64 (2): 1037-1053. [PMID:33417443]
2. Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI. (2015)
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.
Am J Physiol Gastrointest Liver Physiol, 309 (6): G455-65. [PMID:26206858]
3. Kulke MH, Hörsch D, Caplin ME, Anthony LB, Bergsland E, Öberg K, Welin S, Warner RR, Lombard-Bohas C, Kunz PL et al.. (2017)
Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.
J Clin Oncol, 35 (1): 14-23. [PMID:27918724]
4. Lamarca A, Barriuso J, McNamara MG, Hubner RA, Valle JW. (2016)
Telotristat ethyl: a new option for the management of carcinoid syndrome.
Expert Opin Pharmacother, 17 (18): 2487-2498. [PMID:27817224]
5. Margolis KG, Stevanovic K, Li Z, Yang QM, Oravecz T, Zambrowicz B, Jhaver KG, Diacou A, Gershon MD. (2014)
Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.
Gut, 63 (6): 928-37. [PMID:23749550]