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Synonyms: Hp-TGM
Compound class:
Peptide or derivative
Comment: Hp-TGM is a fully functional mimic of the mammalian pro-tolerogenic cytokine TGF-β that is secreted by the intestinal helminth parasite Heligmosomoides polygyrus [1]. Hp-TGM replicates the receptor interaction, downstream signalling and anti-inflammatory activity (by activating host immunosuppressive regulatory T cells) of TGF-β, despite sharing no structural homology with the host cytokine. The activity profile of this peptide suggests potential for therapeutic application. The cDNA sequence for Hp-TGM is submitted to NCBI with accession MG099712.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM et al.. (2017)
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nat Commun, 8 (1): 1741. [PMID:29170498] |
