Synonyms: BMS962212 | compound 55 [PMID: 29077405]
Compound class:
Synthetic organic
Comment: BMS-962212 is a reversible, direct, and highly selective small molecule inhibitor of the serine protease FXIa [2].
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References |
1. Perera V, Luettgen JM, Wang Z, Frost CE, Yones C, Russo C, Lee J, Zhao Y, LaCreta FP, Ma X et al.. (2018)
First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects. Br J Clin Pharmacol, 84 (5): 876-887. [PMID:29346838] |
2. Pinto DJP, Orwat MJ, Smith 2nd LM, Quan ML, Lam PYS, Rossi KA, Apedo A, Bozarth JM, Wu Y, Zheng JJ et al.. (2017)
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). J Med Chem, 60 (23): 9703-9723. [PMID:29077405] |