Synonyms: GKT-137831 | GKT-831 | GKT137831 | GKT831 [3]
Compound class:
Synthetic organic
Comment: Setanaxib (GKT137831) is an investigational dual NOX1/NOX4 inhibitor [1]. It has shown anti-inflammatory activity in models of liver fibrosis [1] and retinopathy [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C et al.. (2012)
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56 (6): 2316-27. [PMID:22806357] |
2. Deliyanti D, Wilkinson-Berka JL. (2015)
Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina. J Neuroinflammation, 12: 136. [PMID:26219952] |
3. van der Vliet A, Danyal K, Heppner DE. (2018)
Dual oxidase: a novel therapeutic target in allergic disease. Br J Pharmacol, 175 (9): 1401-1418. [PMID:29405261] |