Synonyms: GW-791343
Compound class:
Synthetic organic
Comment: GW791343 is an negative allosteric modulator of the human P2X7 receptor, but is a positive modulator of the rat orthologue [1]. Mutational studies suggest that amino acid 95 is a key residue in determining the species difference in antagonist effects [2]. The position 95 residue is phenylalanine in human P2X7 receptors, and leucine in rat.
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