[125I]HPP-HOE140   Click here for help

GtoPdb Ligand ID: 11436

Synonyms: [125I]-3-4-hydroxyphenyl-propionyl-d-Arg0-[Hyp3,Thi5,d-Tic7,Oic8]bradykinin [2]
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide or derivative
Comment: This is a radio-labelled antagonist probe for B2 receptors [1-3]. It is a derivative of icatibant (HOE140).
Peptide Sequence Click here for help
RRPXGXSXXR
D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg
Chemical Modification
Arg1 = hydroxyphenyl-propionyl-D-Arg and is an addition to the BK sequence and is sometimes identified as residue 0; X4 = Hyp (4-Hydroxyproline), X6 = Thi (3-Thienylalanine), X8 = Tic (3-Carboxyisoquinoline), X9 = Oic (2-Carboxyoctahydroindole)