ω-grammotoxin SIA   Click here for help

GtoPdb Ligand ID: 2539

Synonyms: ω-GrTx SIA | omega-grammotoxin SIA | omega-GsTx SIA | omega-GTX SIA
Compound class: Peptide or derivative
Comment: ω-Grammotoxin SIA (GrTx) is a 36 amino acid residue protein toxin from the venom of the spider Grammostola rosea (Chilean rose tarantula) [3].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
DCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSV
Asp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val
Selected 3D Structures
PDB Id: 1KOZ
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
C-terminal valine residue is predicted to be valine-amide; disulphide bond formation between cysteine residues at positions 2 and 16, 9 and 21, and 15 and 30.