growth arrest specific protein 6

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Ligands
growth arrest specific protein 6 (Human)

GtoPdb Ligand ID: 4935

Abbreviated name: Gas6

Synonyms: AXL receptor tyrosine kinase ligand

Compound class: Endogenous peptide in human, mouse or rat

Comment: GAS6 is the sole ligand for AXL receptor tytrosine kinase. Because of AXL's roles in cancer, fibrosis and viral infection, GAS6 has emerged as an attractive target for drug development.

Species: Human

Peptide Sequence
ALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFA TCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSS DGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKL SQDMDTCELEAGWPCPRHRRDGSPAARPGRGAQGSRSEGHIPDRRGPRPWQDILPCVPFSVAKSVKSLYLGRMFSGTPVI RLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEEL ARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTR MQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKK LKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLP DVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA

Peptide Sequence

ALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFA
TCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSS
DGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKL
SQDMDTCELEAGWPCPRHRRDGSPAARPGRGAQGSRSEGHIPDRRGPRPWQDILPCVPFSVAKSVKSLYLGRMFSGTPVI
RLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEEL
ARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTR
MQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKK
LKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLP
DVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA

Selected 3D Structures

PDB Id: 1h30

Image of ligand 3D structure from RCSB PDB

Post-translational Modification
N-linked glycosylation of asparagine residue at position 433; disulphide bond formation between cysteine residues at positions 232 and 247, 296 and 583, 457 and 483, and 656 and 683. Predicted disulphide bond formation between cysteine residues at positions 35 and 40, 90 and 103, 95 and 112, 114 and 123, 130 and 141, 137 and 150, 152 and 165, 171 and 182, 177 and 191, 193 and 206, 212 and 231, 217 and 230, 232 and 247, 296 and 583, 457 and 483, and 656 and 683

Post-translational Modification

N-linked glycosylation of asparagine residue at position 433; disulphide bond formation between cysteine residues at positions 232 and 247, 296 and 583, 457 and 483, and 656 and 683. Predicted disulphide bond formation between cysteine residues at positions 35 and 40, 90 and 103, 95 and 112, 114 and 123, 130 and 141, 137 and 150, 152 and 165, 171 and 182, 177 and 191, 193 and 206, 212 and 231, 217 and 230, 232 and 247, 296 and 583, 457 and 483, and 656 and 683