Synonyms: BHV-4157 | BHV-4157a | BHV4157 | BHV4157a | FC-4157 | trigriluzole
Compound class:
Synthetic organic
Comment: Troriluzole (BHV-4157) is a prodrug of the voltage-dependent calcium channel blocker riluzole. Chemically it is riluzole conjugated to a tripeptide carrier (IUPAC sequence H-Gly-Gly-Sar-Unk, where Unk = the riluzole component), and the active moiety is released by peptidases in vivo. The prodrug is more stable than riluzole and is suitable for once-daily dosing.
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Classification | |
Compound class | Synthetic organic |
Is prodrug? | Yes |
Active form | riluzole |
International Nonproprietary Names | |
INN number | INN |
10784 | troriluzole |
Synonyms |
BHV-4157 | BHV-4157a | BHV4157 | BHV4157a | FC-4157 | trigriluzole |
Database Links | |
CAS Registry No. | 1926203-09-9 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4297586 |
DrugBank Ligand | DB15079 |
GtoPdb PubChem SID | 440816744 |
PubChem CID | 121488186 |
Search Google for chemical match using the InChIKey | YBZSGIWIPOUSHY-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | YBZSGIWIPOUSHY |
Search PubMed clinical trials | troriluzole |
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UniChem Compound Search for chemical match using the InChIKey | YBZSGIWIPOUSHY-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YBZSGIWIPOUSHY-UHFFFAOYSA-N |