vipivotide tetraxetan   Click here for help

GtoPdb Ligand ID: 11982

Synonyms: PSMA-617 | PSMA617
Compound class: Synthetic organic
Comment: Vipivotide tetraxetan (PSMA-617) is a potent PSMA (prostate-specific membrane antigen) inhibitor [1], that was designed for the treatrment of PSMA-positive hormone-relapsed metastatic prostate cancer. It has a DOTA moiety (= tetraxetan) that acts as a radionuclide-chelating domain.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 25
Hydrogen bond donors 11
Rotatable bonds 32
Topological polar surface area 365.19
Molecular weight 1041.5
XLogP -1.13
No. Lipinski's rules broken 3
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(CN1CCN(CCN(CCN(CC1)CC(=O)O)CC(=O)O)CC(=O)O)NCC1CCC(CC1)C(=O)N[C@H](C(=O)NCCCC[C@@H](C(=O)O)NC(=O)N[C@H](C(=O)O)CCC(=O)O)Cc1ccc2c(c1)cccc2
Isomeric SMILES C1CC(CCC1CNC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](Cc1cc2ccccc2cc1)C(=O)NCCCC[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI InChI=1S/C49H71N9O16/c59-40(28-55-17-19-56(29-42(62)63)21-23-58(31-44(66)67)24-22-57(20-18-55)30-43(64)65)51-27-32-8-12-35(13-9-32)45(68)52-39(26-33-10-11-34-5-1-2-6-36(34)25-33)46(69)50-16-4-3-7-37(47(70)71)53-49(74)54-38(48(72)73)14-15-41(60)61/h1-2,5-6,10-11,25,32,35,37-39H,3-4,7-9,12-24,26-31H2,(H,50,69)(H,51,59)(H,52,68)(H,60,61)(H,62,63)(H,64,65)(H,66,67)(H,70,71)(H,72,73)(H2,53,54,74)/t32?,35?,37-,38-,39-/m0/s1
InChI Key JBHPLHATEXGMQR-VLOIPPKDSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(2S)-2-[[(1S)-1-carboxy-5-[[(2S)-3-naphthalen-2-yl-2-[[4-[[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]methyl]cyclohexanecarbonyl]amino]propanoyl]amino]pentyl]carbamoylamino]pentanedioic acid
International Nonproprietary Names Click here for help
INN number INN
11010 vipivotide tetraxetan
Synonyms Click here for help
PSMA-617 | PSMA617
Database Links Click here for help
BindingDB Ligand 50544833
CAS Registry No. 1702967-37-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL4594280
GtoPdb PubChem SID 464244123
PubChem CID 122706786
Search Google for chemical match using the InChIKey JBHPLHATEXGMQR-VLOIPPKDSA-N
Search Google for chemicals with the same backbone JBHPLHATEXGMQR
Search PubMed clinical trials vipivotide tetraxetan
Search PubMed titles vipivotide tetraxetan
Search PubMed titles/abstracts vipivotide tetraxetan
UniChem Compound Search for chemical match using the InChIKey JBHPLHATEXGMQR-VLOIPPKDSA-N
UniChem Connectivity Search for chemical match using the InChIKey JBHPLHATEXGMQR-VLOIPPKDSA-N