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Molecular properties generated using the CDK
|Compound class||Natural product or derivative|
|(+)-staurosporine | antibiotic 230 | antibiotic AM-2282|
|Staurosporine is a non-specific, ATP-competitive inhibitor of protein kinase C (PKC) isolated from a Streptomyces strain . It inhibits all PKC enzyme isoforms [2,12], but has a more potent inhibitory effect on PKCs associated with the cell membrane compared to cytosolic PKCs.
Staurosporine analogues such as midostaurin and 7-hydroxystaurosporine are being investigated as therapeutics.
|CAS Registry No.||62996-74-1|
|GtoPdb PubChem SID||135652717|
|RCSB PDB Ligand||STU|
|Search Google for chemical match using the InChIKey||HKSZLNNOFSGOKW-FYTWVXJKSA-N|
|Search Google for chemicals with the same backbone||HKSZLNNOFSGOKW|
|Search UniChem for chemical match using the InChIKey||HKSZLNNOFSGOKW-FYTWVXJKSA-N|
|Search UniChem for chemicals with the same backbone||HKSZLNNOFSGOKW|
81547 (in complex with death associated protein kinase 1)
81546 (in complex with mitogen-activated protein kinase kinase 6)
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Cat. No. 1285