cariprazine   Click here for help

GtoPdb Ligand ID: 7671

Synonyms: Reagila® | RGH 188 | RGH-188 | Vraylar®
Approved drug PDB Ligand
cariprazine is an approved drug (FDA (2015), EMA (2017))
Compound class: Synthetic organic
Comment: Cariprazine is an antipsychotic. Our structure was drawn from the INN record which shows stereo-chemistry for this compound. PubChem have a record only for the non-chiral molecule, with CID 11154555. The compound is liphophilic meaning that it can easily cross the blood-brain barrier, to reach its site of action [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: cariprazine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 38.82
Molecular weight 426.2
XLogP 4.37
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(N(C)C)NC1CCC(CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl
Isomeric SMILES O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl
InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
InChI Key KPWSJANDNDDRMB-QAQDUYKDSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2015), EMA (2017))
IUPAC Name Click here for help
3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
International Nonproprietary Names Click here for help
INN number INN
8920 cariprazine
Synonyms Click here for help
Reagila® | RGH 188 | RGH-188 | Vraylar®
Database Links Click here for help
Specialist databases
GPCRdb Ligand cariprazine
Other databases
CAS Registry No. 839712-12-8
ChEMBL Ligand CHEMBL2028019
DrugCentral Ligand 5037
GtoPdb PubChem SID 223366006
PubChem CID 11154555
RCSB PDB Ligand 7RU
Search Google for chemical match using the InChIKey KPWSJANDNDDRMB-QAQDUYKDSA-N
Search Google for chemicals with the same backbone KPWSJANDNDDRMB
Search PubMed clinical trials cariprazine
Search PubMed titles cariprazine
Search PubMed titles/abstracts cariprazine
UniChem Compound Search for chemical match using the InChIKey KPWSJANDNDDRMB-QAQDUYKDSA-N
UniChem Connectivity Search for chemical match using the InChIKey KPWSJANDNDDRMB-QAQDUYKDSA-N
Wikipedia Cariprazine