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The IUPHAR/BPS Guide to PHARMACOLOGY complete ligand list

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Low molecular weight, non-polymeric compounds produced via either total synthesis or semi-synthetic processes.
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Ligand name ID Synonyms
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852A Immunopharmacology Ligand 9025
A011 12776 compound 8d [Zhang et al., 2023]
A1120 PDB Ligand 8792 A 1120, compound 33 [PMID: 24835984]
A-1165442 12757 A1165442, compound 52 [PMID: 25100568]
A-119637 490 A 119637, A119637
A-123189 491 A 123189, A123189
A-1262543 13181 A1262543
A-1331852 11102 A 1331852, A1331852
A134974 5130 A 134974, A-134974
A192621 1009 A 192621, A-192621
A-196 PDB Ligand 8949
A286982 Immunopharmacology Ligand 6592 A 286982, A-286982
A-304121 1258 A 304121, A304121
A317491 PDB Ligand 4115 A 317491, A-317491
A-317567 4116 A 317567, A317567
A-317920 1216 A 317920, A317920
A331440 4023 A 331440, A-331440
A-349821 1217 A 349821, A-349,821, A349821
A-366 PDB Ligand 8238 A 366, A366
A-381393 8441 A 381393, A-381,393
A-395 9525
A412997 3301 A-412,997, A-412997
A425619 4117 A 425619, A-425619
A438079 Immunopharmacology Ligand 4118 A 438079, A-438079
A-443654 PDB Ligand 8204 A 443654, A443654
A-582941 3995 A 582941, A582941
A61603 480 A 61603, A-61603
A-674563 PDB Ligand 5655 A 674563, A674563
A68930 6077 A 68930, A 70108, A 70360, A-68930, A-70108, A-70360, A70108, A70360
A740003 4119 A 740003, A-740003
A-769662 PDB Ligand 10069 A769662
A77636 9637 A-77636
A778317 4120 A 778317, A-778317
A-794278 6354 A 794278, A794278, compound 1ac [PMID: 16279797]
A-794282 6211 A 794282, A794282, compound 1n [PMID: 16279797]
A-803467 PDB Ligand 5734 A 803467, A803467
A804598 4121 A 804598, A-804598
A839977 4122 A 839977, A-839977
A-841720 3953 A 841720, A841720
A-850002 6355 A 850002, A850002, compound 28b [PMID: 16279797]
A-85380 5460 A 85380, A85380
A-867744 3986 A 867744, A867744
A-908292 10669
A-910 13579 A910, compound 49 [PMID: 39283694]
A-935142 7661 A 935142, A935142
A947 12308
A-967079 6280 A 967079, A967079
A-971432 9496
[3H]A317491 Ligand is labelled Ligand is radioactive PDB Ligand 5407 [3H]A 317491, [3H]A-317491
[3H]A-585539 Ligand is labelled Ligand is radioactive 3974
[3H]A778317 Ligand is labelled Ligand is radioactive 4076
[3H]A804598 Ligand is labelled Ligand is radioactive 5408 [3H]A 804598
[3H]A81988 Ligand is labelled Ligand is radioactive 3938 [3H]-A81988
A2315A 10846
AAE-M-PBP-amine 8289 acetylaminoethyl-methyl-phenylbutoxyphenyl-amine
AAZ-A-154 13552
AB928 PDB Ligand Immunopharmacology Ligand 11154 AB-928
abacavir Approved drug PDB Ligand 11152 ABC, 1592U89, Ziagen®
Abbott 14c 5871 2,4-diaminopyrimidine-based antagonist, 14c
ABBV-318 12002 ABBV318, compound 73 [PMID: 35436748]
ABBV-3221 10577 ABBV/GLPG-3221, compound 19 [PMID: 31749908]
ABBV-744 PDB Ligand 10730 ABBV 744, ABBV744
ABBV-CLS-484 PDB Ligand 11968 AC484
ABD-1970 11816 ABD1970
abediterol Immunopharmacology Ligand 9326 LAS-100977
abemaciclib Approved drug PDB Ligand 7382 CS-1230, HY-16297A, LY 2835219, LY-2835219 , LY2835219, Verzenio®, Verzenios®
abexinostat 8366 CRA-024781, CRA-24781, PCI-24781
abimtrelvir 11870
abiraterone PDB Ligand 6745
abiraterone acetate Approved drug 9288 Yonsa®, Zytiga®
abivertinib 10044 AC0010, AC0010MA, avitinib (superceded INN), FUJOVEE®
ABL127 8608 ABL 127, ABL-127, compound 1 [PMID: 21639134]
AB-MECA 416
[125I]AB-MECA Ligand is labelled Ligand is radioactive 436 [125I]-AB-MECA, [125I]5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyl-oxolane-2-carboxamide, [125I]N(6)-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide
AB-NECA 434 aminobenzyl-5'-N-ethylcarboxamidoadenosine
abnormal cannabidiol PDB Ligand 5526 Abn-CBD, CAY10429
[125I]ABOPX Ligand is labelled Ligand is radioactive 452 [125I]3-(3,4-aminobenzyl)-8-(4-oxyacetate)phenyl-1-propyl-xanthine
abrocitinib Approved drug PDB Ligand Immunopharmacology Ligand 9991 Cibinqo®, compound 25 [PMID: 29298069], PF-04965842, PF04965842
ABT-239 1218 ABT 239, ABT239
ABT-288 6927 ABT 288, ABT288
ABT-299 1849 ABT 299, ABT299
ABT-384 7357 ABT 384, ABT384
ABT-491 PDB Ligand 1850 ABT 491, ABT491
ABT-639 7721 ABT 639, ABT639
ABT-670 8439 ABT 670, ABT670, compound 6b [PMID 17149874]
ABT702 5131 ABT 702, ABT-702
ABT-737 PDB Ligand Immunopharmacology Ligand 8320 ABT 737, ABT737, compound 2 [PMID 17256834]
ABX-002 12973 ABX002, compound 1 [WO2022236133A1]
ABX-1431 10062 ABX1431, compound 28 [PMID: 30067909], compound 9aq [WO2013103973A1], example 82 [WO2013103973A1]
AC-186 8897 AC 186
AC1903 10290 AC-1903
AC-260584 334 AC 260584, AC260584
AC261066 4054 AC 261066, AC-261066
AC262620 4017 AC 262620, AC-262620
AC262970 4018 AC 262970, AC-262970
AC263093 4020 AC 263093, AC-263093
AC264613 9460 AC-264613, compound 3 [PMID: 18720984]
AC265347 3947 AC 265347, AC-265347
AC-42 289 AC 42, AC42
AC430 Immunopharmacology Ligand 9177 AC-430
AC45594 5422 4-(heptyloxy)benzolol, 4-heptoxyphenol
AC-55541 9456 AC55541
AC55649 4055 AC 55649, AC-55649
AC710 8095 AC 710, AC-710
AC-7954 2151 AC 7954, AC7954
AC-90179 174 AC 90179, AC90179
AC-98170 9457 AC98170
ACAA PDB Ligand 2443 ACA
acadesine 5133 AICA-riboside, AR-100, SCH-900395
acalabrutinib Approved drug PDB Ligand Immunopharmacology Ligand 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
acalisib 10096 CAL-120, GS-9820
acamprosate Approved drug 7106 Campral®
acarbose Approved drug PDB Ligand 6791 BAY-G 5421, BAY-G-5421, Glucobay®, Precose®
7ACC2 PDB Ligand 8818 compound 19 [PMID: 24095010]
Ac-DEVD-CHO 6527
ACDPP 3388
acebilustat PDB Ligand 11984 CTX-4430, CTX4430
acebutolol Approved drug 7107 IL-17803A, Sectral®
(+)-aceclidine 286 S-(+)-aceclidine
(-)-aceclidine 288 R-(-)-aceclidine
acelarin 7389 NUC-1031
acenocoumarol Approved drug 9015 Sinthrome®, Sintrom®
acesulfame PDB Ligand 12460 acetosulfam
ACET PDB Ligand 4123
acetamide PDB Ligand 4661 ethanamide, methylformamide
acetazolamide Approved drug PDB Ligand 6792 Diamox®
acetoacetic acid 4522 acetoacetate, diacetic acid
acetohexamide Approved drug PDB Ligand 6793 Dymelor®
1'-acetoxychavicol acetate 6298
[3H]acetylcholine Ligand is labelled Ligand is radioactive PDB Ligand 8593
[14C]acetylCoA Ligand is labelled Ligand is radioactive 4541 [14C]-acetylCoA
acetylcysteine Approved drug PDB Ligand 10945 Ilube® (eye drops), N-A-C Sustain®, N-Acetyl-cysteine, N-Acetyl-L-cysteine, NAC, Parvolex®
acetyldigitoxin Approved drug 6794 acetyldiginatin, Acylanid®, alpha-acetyldigitoxin
acetyl-podocarpic dimer 2753 APD, acetyl podocarpic acid anhydride
AChE reactivator 2 10074
ACHN-975 PDB Ligand 13333
aciclovir Approved drug PDB Ligand 4829 acyclovir, Zovirax®
acifran 1595 AY-25712, D02753, reductol
acipimox Approved drug 1596 Olbetam®
acitretin Approved drug 7598 Ro-101670000, Soriatane®
acivicin PDB Ligand 11402 AT-125, AT125, U 42,126, U-42,126, U-42126
aclidinium Approved drug 7449 LAS W-330, LAS-34273, Tudorza Pressair®
acloproxalap 12097 Compound 5 [WO2020223685A1]
A101-(CONH2)-B322 13122
acorafloxacin 10753 avarofloxacin (former name), JNJ-Q2, JNJQ2
acoramidis Approved drug PDB Ligand 13628 AG-10, AG10, Attruby®
[35S]ACPPB Ligand is labelled Ligand is radioactive 4584 [35S]-ACPPB
ACPT-I 1408 1-aminocyclopentane-1,3,4-tricarboxylic acid
ACQ090 2076 NVP ACQ090
acrizanib 12782 compound 35 [PMID: 29400470], LHA-510, LHA510
acrolein 2418 propenal
acrylamide PDB Ligand 4553
4-acryloylphenol 8841 compound 6
ACT001 13291 ACT-001
ACT-1014-6470 Immunopharmacology Ligand 12326 example 172 [WO2019137927A1], Ic-58
ACT-1016-0707 13337 compound 49 [PMID: 38349250]
ACT-335827 9122 ACT 335827, compound 9 [PMID: 23589487]
ACT-389949 Immunopharmacology Ligand 9511
ACT-451840 Antimalarial Ligand 10022 ACT451840, Actelion-451840
ACT-462206 PDB Ligand 9303 compound 24 [PMID: 25147058]
ACT-660602 Immunopharmacology Ligand 12207 ACT660602, compound 9j [PMID: 35947786]
ACT-709478 PDB Ligand 12647 ACT709478, compound 66b [PMID: 29116786], NBI-827104, NBI827104
ACT-777991 Immunopharmacology Ligand 12584 ACT777991, compound 8a [PMID: 36883854]
acumapimod Immunopharmacology Ligand 9203 BCT 197, BCT-197, BCT197, compound A [WO2013139809]
Ac-VEID-CHO 8566 acetyl-Val-Ile-Asp-aldehyde
ACY-738 11120 example 73 [WO2012068109A2]
AD-5061 2663 AD 5061, AD 7057, AD-7057, AD5061, AD7057
AD5075 2701 AD 5075, AD-5075
[3H]AD5075 Ligand is labelled Ligand is radioactive 2702 [3H]-AD5075
adagrasib Approved drug PDB Ligand 10888 compound 20 [PMID: 32250617], Krazati®, MRTX-849, MRTX849
adapalene Approved drug 5429 Differin®
adavosertib PDB Ligand 7702 AZD 1775, AZD-1775, AZD1775, MK-1775, MK1775
adenophostin A 4124
ADG-207 11068
ADL5747 9003 ADL 5747, ADL-5747, compound 36 [PMID: 19694468]
ADL5859 9004 ADL 5859, ADL-5859, compound 20 [PMID: 18788723]
adomeglivant 9479 LY-2409021, LY2409021
ADPβS PDB Ligand 1755 adenosine 5'-O-(2-thiodiphosphate), ADPbetaS
[35S]ADPβS Ligand is labelled Ligand is radioactive 3408
adriforant Immunopharmacology Ligand 8985 PF 3893787, PF-03893787, ZPL-389, ZPL-3893787, ZPL389, ZPL3893787
adrixetinib 12375 example 7 [US2021163448A1]
(+)-ADTN 932 (+)-ADTN (aminotetralin-6,7-diol)
ADU-S100 Immunopharmacology Ligand 10192 dithio-(Rp,Rp)-[cyclic[A(2',5')pA(3',5')p]], MIW815, ML RR-S2 CDA, S100
ADX-47273 1420 ADX 47273, ADX47273
ADX71743 6217 ADX 71743, ADX-71743
ADX88178 PDB Ligand 6238 ADX 88178, ADX-88178
AE9C90CB 8586
AEE788 PDB Ligand 7643 AEE 788, NVP-AEE788
3-AESA 13325 3-(2-aminoethyl)-2-hydroxybenzoic acid
AF353 4125 AF 353, AF-353
AF-906 9538 compound 128 [PMID: 26686393], Ro-51
afabicin 10754 AFN-1720, Debio 1450, Debio1450
afatinib Approved drug PDB Ligand 5667 BIBW2992, Gilotrif®
AFD(R) 2937
AFDX384 3264 AF-DX 384, AFDX-384
[3H]AF DX-384 Ligand is labelled Ligand is radioactive 368 [3H]AF-DX 384
afegostat PDB Ligand 7410 IFM, iso-fagomine, isofagomine
aficamten PDB Ligand 11524 CK-274, CK-3773274, CK3773274
AFP-07 1962 AFP 07, AFP07
afuresertib 7890 GSK 2110183, GSK-2110183, GSK2110183
AG-09/1 5833 AG-09/1 [benzimidazole derivative], ST024252
AG 1024 5912 AG-1024, AG1024, tyrphostin AG 1024
AG-11/03 5832 AG-11/03 [benzimidazole derivative], STK220090
AG 112 5913 AG-112, AG112, tyrphostin A48, tyrphostin AG 112
AG-122018 11398 compound 18 [PMID: 25091930]
AG 1295 5914 AG-1295, AG1295
AG 1296 5915 AG-1296, AG1296, tyrphostin AG-1296
AG-14 5835 AG 14, AG14
AG14361 8094 AG 14361, AG-14361
AG1478 PDB Ligand 4862 AG 1478, AG-1478, tyrphostin AG1478
AG-17724 PDB Ligand 11400 AG17724, compound 7 [PMID: 25091930]
AG-26 6268 AG 26, AG26
AG 490 5916 AG-490, tyrphostin AG490, tyrphostin B42
AG879 4863 AG 879, AG-879, tyrphostin AG879
AG 9 5917 AG-9, AG9, tyrphostin 1, tyrphostin A1
agatolimod Immunopharmacology Ligand 9843 CpG 7909, CpG7909, PF 3512676, PF-3512676, ProMune, VaxImmune
agerafenib 7880 AC013773, CEP 32496, CEP-32496, CEP32496, RXDX-105
AGI-5198 9240
AGK2 8099 AGK 2, AGK-2
AGL 2043 5918 AGL-2043, AGL2043, HMS3229A05
AGN 191976 6071 AGN-191976, AGN191976
AGN192093 3387 AGN 192093, AGN-192093
AGN193109 2640 AGN 193109, AGN-93109
AGN193836 2649 AGN 193836, AGN-193836
AGN194204 2811 AGN 194204, AGN-194204
AGN 211334 5455 AGN-211334, AGN211334
agomelatine Approved drug PDB Ligand 198 S20098, Thymanax®, Valdoxan®
AG-041R 901 AG 041R, AG041R, LS-83786
AGS-499 13261
AGU654 Immunopharmacology Ligand 13646 AGU-654, compound 44 [PMID: 39622054]
AH10-7 Immunopharmacology Ligand 9899
AH 11110 8461 AH-11110, AH11110
AH13205 1928 AH 13205, AH-13205
AH23848 1949 (-)-AH23848, (-)AH23848, AH 23848, AH-23848
AH6809 Immunopharmacology Ligand 1896 AH 6809, AH-6809
(S)-4-AHCP PDB Ligand 4069
AHPN 3431 CD 437, CD437, Ro 47-2077
AH23848 (racemic) 1950 AH 23848, AH-23848
AIDA 1376 GNF-Pf-1401, UPF 523, UPF523
AIM-1290 Antimalarial Ligand 11823
AJ2-30 Immunopharmacology Ligand 13090 compound 4 [PMID: 38191941]
(+)-AJ76 970
AK198 PDB Ligand 8637
AK-2292 12409 AK2292
AKK(thioAc)LM21 8816
AKN-028 7969 AKN 028, AKN028
Akt inhibitor IV 5919 GNF-PF-254
Akt inhibitor VIII PDB Ligand 5921 isozyme-selective, Akti-1/2
Akt inhibitor X PDB Ligand 5922 10-DEBC, NCGC00167772-01
AL12180 3386 5,6-dihydro-4,5-didehydro-11-deoxy-11-oxa-16-(3-chlorophenoxy)-ω-tetranor-PGF2α, AL-12180
AL-8810 1956 AL 8810, AL8810
AL-37350A 160 AL 37350A, AL37350A
alalevonadifloxacin 10756 WCK 2349, WCK-2349, WCK2349
Ala(1-naph)-Pro-CN 8607
[14C]alanine Ligand is labelled Ligand is radioactive PDB Ligand 4542 [14C]-alanine
[3H]alanine Ligand is labelled Ligand is radioactive PDB Ligand 4543 [3H]-alanine
albitiazolium Antimalarial Ligand 10407 SAR97276, SAR97276A, T3
alcaftadine Approved drug Immunopharmacology Ligand 7587 Lastacaft®, R-89674
[3H]aldosterone Ligand is labelled Ligand is radioactive PDB Ligand 3452 [3H]-aldosterone
aldumastat PDB Ligand 12778 GLPG-1972, GLPG1972, S201086
alectinib Approved drug PDB Ligand 7739 AF802, Alecensa®, CH5424802
aleglitazar PDB Ligand 7405 R-1439, Ro-0728804
alemcinal 1444 ABT 229, ABT-229, ABT229
alendronate Approved drug PDB Ligand 3141 ABDP, BPH 1, Fosamax®, MK-217
Alexa-488-telenzepine Ligand is labelled 8600
alfentanil Approved drug 7108 Alfenta®, R-39209, Rapifen®
alfuzosin Approved drug 7109 SL-77499-10, SL-7749910, Uroxatral®
alimemazine Approved drug Immunopharmacology Ligand 7237 Nedeltran®, trimeprazine
alisertib PDB Ligand 7790 MLN-8237
aliskiren Approved drug PDB Ligand 4812 CGP-060536B, SPP100, Tekturna®
alizapride Approved drug 11141 Limican®, Litican®, Nausilex®, Plitican®, Superan®, Vergentan®
alkylbenzene sulfonate 2362
alkyl glycerol phosphate 18:1 6994 AGP 18.1
alkyl OMPT 2913
allitinib 9912 ALL-3, AST-1306, AST1306
allopurinol Approved drug 6795 Aloprim®, BW-56-158, BW-56158, Zyloprim®
allosteric modulator 33 [PMID: 35878399] PDB Ligand 12071 compound 33 [PMID: 35878399]
alloswitch-1 PDB Ligand 8543 trans-alloswitch-1
alloxazine 456 alloxazin, isoalloxazine
all-trans-4-oxo-retinoic acid 2741 4-oxoretinoic acid, Ro 12-4824
1-allyl-2-[3-(isopropylamino)propoxy]-9H-carbazole 3136
1-allyl-2-[3-(isopropylamino)propoxy]-9H-xanthen-9-one <