fedratinib

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value (-log10) Parameter Value (nM) Parameter
cyclin G associated kinase GAK Hs Inhibitor Inhibition 9.0 pKd 1.1 Kd
Janus kinase 2 JAK2(JH1domain-catalytic) Hs Inhibitor Inhibition 9.0 pKd 1.1 Kd
death associated protein kinase 3 DAPK3 Hs Inhibitor Inhibition 8.9 pKd 1.2 Kd
fms related receptor tyrosine kinase 3 FLT3(D835H) Hs Inhibitor Inhibition 8.3 pKd 4.9 Kd
fms related receptor tyrosine kinase 3 FLT3(D835Y) Hs Inhibitor Inhibition 8.2 pKd 6.4 Kd
serine/threonine kinase 16 STK16 Hs Inhibitor Inhibition 8.2 pKd 6.6 Kd
doublecortin like kinase 3 DCAMKL3 Hs Inhibitor Inhibition 7.9 pKd 13.0 Kd
fms related receptor tyrosine kinase 3 FLT3 Hs Inhibitor Inhibition 7.9 pKd 13.0 Kd
fms related receptor tyrosine kinase 3 FLT3(K663Q) Hs Inhibitor Inhibition 7.9 pKd 13.0 Kd
death associated protein kinase 1 DAPK1 Hs Inhibitor Inhibition 7.8 pKd 16.0 Kd
fms related receptor tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 7.8 pKd 16.0 Kd
Janus kinase 1 JAK1(JH1domain-catalytic) Hs Inhibitor Inhibition 7.7 pKd 18.0 Kd
mitogen-activated protein kinase kinase kinase 19 YSK4 Hs Inhibitor Inhibition 7.7 pKd 19.0 Kd
fms related receptor tyrosine kinase 3 FLT3(N841I) Hs Inhibitor Inhibition 7.7 pKd 20.0 Kd
tyrosine kinase 2 TYK2(JH1domain-catalytic) Hs Inhibitor Inhibition 7.7 pKd 21.0 Kd
death associated protein kinase 2 DAPK2 Hs Inhibitor Inhibition 7.5 pKd 29.0 Kd
fms related receptor tyrosine kinase 3 FLT3(R834Q) Hs Inhibitor Inhibition 7.5 pKd 29.0 Kd
BMP2 inducible kinase BIKE Hs Inhibitor Inhibition 7.5 pKd 32.0 Kd
NUAK family kinase 1 ARK5 Hs Inhibitor Inhibition 7.5 pKd 34.0 Kd
AP2 associated kinase 1 AAK1 Hs Inhibitor Inhibition 7.5 pKd 35.0 Kd
FYN proto-oncogene, Src family tyrosine kinase FYN Hs Inhibitor Inhibition 7.4 pKd 38.0 Kd
salt inducible kinase 1 SIK Hs Inhibitor Inhibition 7.4 pKd 39.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(E255K)-phosphorylated Hs Inhibitor Inhibition 7.4 pKd 40.0 Kd
protein tyrosine kinase 2 FAK Hs Inhibitor Inhibition 7.4 pKd 42.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1-phosphorylated Hs Inhibitor Inhibition 7.4 pKd 44.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(H396P)-nonphosphorylated Hs Inhibitor Inhibition 7.3 pKd 45.0 Kd
serine/threonine kinase 17b DRAK2 Hs Inhibitor Inhibition 7.3 pKd 45.0 Kd
platelet derived growth factor receptor beta PDGFRB Hs Inhibitor Inhibition 7.3 pKd 45.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(A829P) Hs Inhibitor Inhibition 7.3 pKd 46.0 Kd
NUAK family, SNF1-like kinase, 2 SNARK Hs Inhibitor Inhibition 7.3 pKd 49.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(M351T)-phosphorylated Hs Inhibitor Inhibition 7.3 pKd 50.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Q252H)-phosphorylated Hs Inhibitor Inhibition 7.3 pKd 54.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Y253F)-phosphorylated Hs Inhibitor Inhibition 7.3 pKd 56.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D) Hs Inhibitor Inhibition 7.2 pKd 58.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(H396P)-phosphorylated Hs Inhibitor Inhibition 7.2 pKd 61.0 Kd
tyrosine kinase non receptor 2 TNK2 Hs Inhibitor Inhibition 7.2 pKd 64.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-phosphorylated Hs Inhibitor Inhibition 7.2 pKd 65.0 Kd
mitogen-activated protein kinase 7 ERK5 Hs Inhibitor Inhibition 7.2 pKd 66.0 Kd
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha PIP5K1A Hs Inhibitor Inhibition 7.2 pKd 66.0 Kd
ret proto-oncogene RET(V804L) Hs Inhibitor Inhibition 7.2 pKd 71.0 Kd
LCK proto-oncogene, Src family tyrosine kinase LCK Hs Inhibitor Inhibition 7.1 pKd 72.0 Kd
Janus kinase 3 JAK3(JH1domain-catalytic) Hs Inhibitor Inhibition 7.1 pKd 74.0 Kd
SRC proto-oncogene, non-receptor tyrosine kinase SRC Hs Inhibitor Inhibition 7.1 pKd 75.0 Kd
unc-51 like autophagy activating kinase 2 ULK2 Hs Inhibitor Inhibition 7.1 pKd 79.0 Kd
ret proto-oncogene RET(V804M) Hs Inhibitor Inhibition 7.1 pKd 81.0 Kd
FGR proto-oncogene, Src family tyrosine kinase FGR Hs Inhibitor Inhibition 7.1 pKd 82.0 Kd
RIO kinase 3 RIOK3 Hs Inhibitor Inhibition 7.0 pKd 91.0 Kd
TANK binding kinase 1 TBK1 Hs Inhibitor Inhibition 7.0 pKd 92.0 Kd
polo like kinase 4 PLK4 Hs Inhibitor Inhibition 7.0 pKd 96.0 Kd
salt inducible kinase 2 SIK2 Hs Inhibitor Inhibition 7.0 pKd 98.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 4 GCN2(Kin.Dom.2,S808G) Hs Inhibitor Inhibition 7.0 pKd 100.0 Kd
RIO kinase 1 RIOK1 Hs Inhibitor Inhibition 7.0 pKd 100.0 Kd
SRSF protein kinase 2 SRPK2 Hs Inhibitor Inhibition 7.0 pKd 100.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Q252H)-nonphosphorylated Hs Inhibitor Inhibition 7.0 pKd 110.0 Kd
cyclin dependent kinase 7 CDK7 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
casein kinase 2, alpha prime polypeptide subunit CSNK2A2 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
interleukin 1 receptor associated kinase 3 IRAK3 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
NIMA related kinase 6 NEK6 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
YES proto-oncogene 1, Src family tyrosine kinase YES Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT Hs Inhibitor Inhibition 6.9 pKd 130.0 Kd
myosin light chain kinase family member 4 MYLK4 Hs Inhibitor Inhibition 6.9 pKd 130.0 Kd
ret proto-oncogene RET Hs Inhibitor Inhibition 6.9 pKd 130.0 Kd
citron rho-interacting serine/threonine kinase CIT Hs Inhibitor Inhibition 6.8 pKd 140.0 Kd
ribosomal protein S6 kinase A4 RPS6KA4(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 6.8 pKd 140.0 Kd
activin A receptor type 1 ACVR1 Hs Inhibitor Inhibition 6.8 pKd 150.0 Kd
NIMA related kinase 8 NEK9 Hs Inhibitor Inhibition 6.8 pKd 150.0 Kd
ret proto-oncogene RET(M918T) Hs Inhibitor Inhibition 6.8 pKd 150.0 Kd
AXL receptor tyrosine kinase AXL Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(D816H) Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(D816V) Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
NIMA related kinase 7 NEK7 Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
phosphatidylinositol-5-phosphate 4-kinase type 2 beta PIP5K2B Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
SRSF protein kinase 1 SRPK1 Hs Inhibitor Inhibition 6.8 pKd 160.0 Kd
G protein-coupled receptor kinase 4 GRK4 Hs Inhibitor Inhibition 6.8 pKd 170.0 Kd
SRSF protein kinase 3 SRPK3 Hs Inhibitor Inhibition 6.8 pKd 170.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317L)-phosphorylated Hs Inhibitor Inhibition 6.7 pKd 180.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1-nonphosphorylated Hs Inhibitor Inhibition 6.7 pKd 180.0 Kd
doublecortin like kinase 1 DCAMKL1 Hs Inhibitor Inhibition 6.7 pKd 190.0 Kd
fyn related Src family tyrosine kinase FRK Hs Inhibitor Inhibition 6.7 pKd 200.0 Kd
mitogen-activated protein kinase 10 JNK3 Hs Inhibitor Inhibition 6.7 pKd 200.0 Kd
homeodomain interacting protein kinase 4 HIPK4 Hs Inhibitor Inhibition 6.7 pKd 220.0 Kd
interleukin 1 receptor associated kinase 1 IRAK1 Hs Inhibitor Inhibition 6.7 pKd 220.0 Kd
protein tyrosine kinase 2 beta PYK2 Hs Inhibitor Inhibition 6.7 pKd 220.0 Kd
serine/threonine kinase 33 STK33 Hs Inhibitor Inhibition 6.7 pKd 220.0 Kd
SNF related kinase SNRK Hs Inhibitor Inhibition 6.6 pKd 230.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-nonphosphorylated Hs Inhibitor Inhibition 6.6 pKd 240.0 Kd
mitogen-activated protein kinase 9 JNK2 Hs Inhibitor Inhibition 6.6 pKd 240.0 Kd
mitogen-activated protein kinase 8 JNK1 Hs Inhibitor Inhibition 6.6 pKd 260.0 Kd
unc-51 like autophagy activating kinase 1 ULK1 Hs Inhibitor Inhibition 6.6 pKd 270.0 Kd
fibroblast growth factor receptor 1 FGFR1 Hs Inhibitor Inhibition 6.6 pKd 280.0 Kd
polo like kinase 1 PLK1 Hs Inhibitor Inhibition 6.6 pKd 280.0 Kd
unc-51 like kinase 3 ULK3 Hs Inhibitor Inhibition 6.5 pKd 290.0 Kd
coenzyme Q8B ADCK4 Hs Inhibitor Inhibition 6.5 pKd 300.0 Kd
calcium/calmodulin-dependent protein kinase II alpha subunit CAMK2A Hs Inhibitor Inhibition 6.5 pKd 300.0 Kd
EPH receptor B6 EPHB6 Hs Inhibitor Inhibition 6.5 pKd 300.0 Kd
microtubule affinity regulating kinase 3 MARK3 Hs Inhibitor Inhibition 6.5 pKd 300.0 Kd
serine/threonine kinase 11 LKB1 Hs Inhibitor Inhibition 6.5 pKd 310.0 Kd
phosphorylase kinase catalytic subunit gamma 1 PHKG1 Hs Inhibitor Inhibition 6.5 pKd 330.0 Kd
aurora kinase C AURKC Hs Inhibitor Inhibition 6.5 pKd 350.0 Kd
cyclin dependent kinase 17 PCTK2 Hs Inhibitor Inhibition 6.5 pKd 350.0 Kd
fibroblast growth factor receptor 3 FGFR3 Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
inhibitor of nuclear factor kappa B kinase subunit beta IKK-beta Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
inhibitor of nuclear factor kappa B kinase subunit epsilon IKK-epsilon Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
mitogen-activated protein kinase kinase 5 MEK5 Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
ribosomal protein S6 kinase A6 RSK4(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
tyrosine kinase non receptor 1 TNK1 Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
MAPK interacting serine/threonine kinase 2 MKNK2 Hs Inhibitor Inhibition 6.4 pKd 380.0 Kd
pre-mRNA processing factor kinase PRP4K PRP4 Hs Inhibitor Inhibition 6.4 pKd 390.0 Kd
WEE1 G2 checkpoint kinase WEE1 Hs Inhibitor Inhibition 6.4 pKd 390.0 Kd
bone morphogenetic protein receptor type IB BMPR1B Hs Inhibitor Inhibition 6.4 pKd 410.0 Kd
ribosomal protein S6 kinase A1 RSK1(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 6.4 pKd 420.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317L)-nonphosphorylated Hs Inhibitor Inhibition 6.3 pKd 450.0 Kd
TTK protein kinase TTK Hs Inhibitor Inhibition 6.3 pKd 450.0 Kd
tyrosine kinase 2 TYK2(JH2domain-pseudokinase) Hs Inhibitor Inhibition 6.3 pKd 450.0 Kd
calcium/calmodulin dependent protein kinase ID CAMK1D Hs Inhibitor Inhibition 6.3 pKd 460.0 Kd
fibroblast growth factor receptor 2 FGFR2 Hs Inhibitor Inhibition 6.3 pKd 470.0 Kd
aurora kinase B AURKB Hs Inhibitor Inhibition 6.3 pKd 490.0 Kd
IL2 inducible T cell kinase ITK Hs Inhibitor Inhibition 6.3 pKd 490.0 Kd
LYN proto-oncogene, Src family tyrosine kinase LYN Hs Inhibitor Inhibition 6.3 pKd 500.0 Kd
mitogen-activated protein kinase 15 ERK8 Hs Inhibitor Inhibition 6.3 pKd 510.0 Kd
myosin light chain kinase MYLK Hs Inhibitor Inhibition 6.3 pKd 520.0 Kd
FES proto-oncogene, tyrosine kinase FES Hs Inhibitor Inhibition 6.3 pKd 530.0 Kd
calcium/calmodulin-dependent protein kinase II gamma subunit CAMK2G Hs Inhibitor Inhibition 6.3 pKd 540.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317I)-phosphorylated Hs Inhibitor Inhibition 6.3 pKd 560.0 Kd
ABL proto-oncogene 2, non-receptor tyrosine kinase ABL2 Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
epidermal growth factor receptor EGFR(L858R,T790M) Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
NIMA related kinase 5 NEK5 Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
epidermal growth factor receptor EGFR(T790M) Hs Inhibitor Inhibition 6.2 pKd 580.0 Kd
mitogen-activated protein kinase kinase kinase 2 MAP3K2 Hs Inhibitor Inhibition 6.2 pKd 580.0 Kd
calcium/calmodulin-dependent protein kinase II delta subunit CAMK2D Hs Inhibitor Inhibition 6.2 pKd 590.0 Kd
mitogen-activated protein kinase kinase kinase 13 LZK Hs Inhibitor Inhibition 6.2 pKd 590.0 Kd
c-ros oncogene 1, receptor tyrosine kinase ROS1 Hs Inhibitor Inhibition 6.2 pKd 600.0 Kd
serine/threonine kinase 17a DRAK1 Hs Inhibitor Inhibition 6.2 pKd 610.0 Kd
colony stimulating factor 1 receptor CSF1R Hs Inhibitor Inhibition 6.2 pKd 620.0 Kd
NIMA related kinase 3 NEK3 Hs Inhibitor Inhibition 6.2 pKd 640.0 Kd
ALK receptor tyrosine kinase ALK Hs Inhibitor Inhibition 6.2 pKd 650.0 Kd
BLK proto-oncogene, Src family tyrosine kinase BLK Hs Inhibitor Inhibition 6.2 pKd 650.0 Kd
ZAK sterile alpha motif and leucine zipper containing kinase AZK ZAK Hs Inhibitor Inhibition 6.2 pKd 650.0 Kd
STE20 like kinase SLK Hs Inhibitor Inhibition 6.2 pKd 680.0 Kd
microtubule affinity regulating kinase 1 MARK1 Hs Inhibitor Inhibition 6.2 pKd 700.0 Kd
tyrosine kinase with immunoglobulin like and EGF like domains 1 TIE1 Hs Inhibitor Inhibition 6.2 pKd 700.0 Kd
EPH receptor A1 EPHA1 Hs Inhibitor Inhibition 6.1 pKd 730.0 Kd
fibroblast growth factor receptor 3 FGFR3(G697C) Hs Inhibitor Inhibition 6.1 pKd 760.0 Kd
TAO kinase 2 TAOK2 Hs Inhibitor Inhibition 6.1 pKd 760.0 Kd
SH3 domain binding kinase 1 SBK1 Hs Inhibitor Inhibition 6.1 pKd 790.0 Kd
muscle associated receptor tyrosine kinase MUSK Hs Inhibitor Inhibition 6.1 pKd 800.0 Kd
MER proto-oncogene, tyrosine kinase MERTK Hs Inhibitor Inhibition 6.1 pKd 820.0 Kd
component of inhibitor of nuclear factor kappa B kinase complex IKK-alpha Hs Inhibitor Inhibition 6.1 pKd 830.0 Kd
neurotrophic receptor tyrosine kinase 1 TRKA Hs Inhibitor Inhibition 6.1 pKd 840.0 Kd
Bruton tyrosine kinase BTK Hs Inhibitor Inhibition 6.1 pKd 850.0 Kd
Insulin receptor INSR Hs Inhibitor Inhibition 6.1 pKd 850.0 Kd
homeodomain interacting protein kinase 1 HIPK1 Hs Inhibitor Inhibition 6.1 pKd 860.0 Kd
cyclin dependent kinase 4 CDK4-cyclinD3 Hs Inhibitor Inhibition 6.1 pKd 870.0 Kd
doublecortin like kinase 2 DCAMKL2 Hs Inhibitor Inhibition 6.1 pKd 870.0 Kd
leucine rich repeat kinase 2 LRRK2 Hs Inhibitor Inhibition 6.1 pKd 870.0 Kd
serine/threonine kinase 36 STK36 Hs Inhibitor Inhibition 6.1 pKd 870.0 Kd
casein kinase 2, alpha 1 polypeptide subunit CSNK2A1 Hs Inhibitor Inhibition 6.0 pKd 920.0 Kd
LIM domain kinase 1 LIMK1 Hs Inhibitor Inhibition 6.0 pKd 940.0 Kd
discoidin domain receptor tyrosine kinase 2 DDR2 Hs Inhibitor Inhibition 6.0 pKd 950.0 Kd
microtubule affinity regulating kinase 4 MARK4 Hs Inhibitor Inhibition 6.0 pKd 970.0 Kd
DM1 protein kinase DMPK Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 1 EIF2AK1 Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
homeodomain interacting protein kinase 2 HIPK2 Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
leucine rich repeat kinase 2 LRRK2(G2019S) Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
FER tyrosine kinase FER Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
protein kinase N1 PKN1 Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 2 PRKR Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
transforming growth factor beta receptor 2 TGFBR2 Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
BMX non-receptor tyrosine kinase BMX Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
protein tyrosine kinase 6 BRK Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
mitogen-activated protein kinase 6 ERK3 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
endoplasmic reticulum to nucleus signaling 1 ERN1 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
interleukin 1 receptor associated kinase 4 IRAK4 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
NIMA related kinase 11 NEK11 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
p21 (RAC1) activated kinase 5 PAK7 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
ribosomal protein S6 kinase A1 RSK1(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
cyclin dependent kinase like 2 CDKL2 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
homeodomain interacting protein kinase 3 HIPK3 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
mitogen-activated protein kinase kinase kinase kinase 1 HPK1 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
mitogen-activated protein kinase kinase kinase 3 MAP3K3 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
TAO kinase 1 TAOK1 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
tousled like kinase 1 TLK1 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
testis specific serine kinase 1B TSSK1B Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
epidermal growth factor receptor EGFR(L747-E749del, A750P) Hs Inhibitor Inhibition 5.8 pKd 1500.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition 5.8 pKd 1500.0 Kd
TXK tyrosine kinase TXK Hs Inhibitor Inhibition 5.8 pKd 1500.0 Kd
calcium/calmodulin dependent protein kinase I CAMK1 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
Insulin receptor-related receptor INSRR Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
NIMA related kinase 4 NEK4 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
phosphorylase kinase catalytic subunit gamma 2 PHKG2 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
polo like kinase 3 PLK3 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
Protein kinase G (PKG) 2 PRKG2 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
serine/threonine kinase 39 STK39 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
megakaryocyte-associated tyrosine kinase CTK Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
EPH receptor B1 EPHB1 Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
NIMA related kinase 2 NEK2 Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
phosphatidylinositol 4-kinase alpha PIK4CB Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
dual serine/threonine and tyrosine protein kinase RIPK5 Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
calcium/calmodulin dependent protein kinase kinase 1 CAMKK1 Hs Inhibitor Inhibition 5.7 pKd 1800.0 Kd
mitogen-activated protein kinase kinase kinase kinase 3 MAP4K3 Hs Inhibitor Inhibition 5.7 pKd 1800.0 Kd
TNNI3 interacting kinase TNNI3K Hs Inhibitor Inhibition 5.7 pKd 1800.0 Kd
discoidin domain receptor tyrosine kinase 1 DDR1 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
ciliogenesis associated kinase 1 ICK Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
SIK family kinase 3 QSK Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
TAO kinase 3 TAOK3 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
TEK receptor tyrosine kinase TIE2 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
CDC like kinase 4 CLK4 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
erb-b2 receptor tyrosine kinase 4 ERBB4 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
fibroblast growth factor receptor 4 FGFR4 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
fms related receptor tyrosine kinase 4 FLT4 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
Janus kinase 1 JAK1(JH2domain-pseudokinase) Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
ribosomal protein S6 kinase B1 S6K1 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
tousled like kinase 2 TLK2 Hs Inhibitor Inhibition 5.7 pKd 2000.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317I)-nonphosphorylated Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
EPH receptor B4 EPHB4 Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
HCK proto-oncogene, Src family tyrosine kinase HCK Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
Rho associated coiled-coil containing protein kinase 1 ROCK1 Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
Insulin-like growth factor I receptor IGF1R Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
Rho associated coiled-coil containing protein kinase 2 ROCK2 Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
ribosomal protein S6 kinase A5 RPS6KA5(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
CDC like kinase 2 CLK2 Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
ribosomal protein S6 kinase A2 RSK3(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
activin A receptor type IL ACVRL1 Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
protein kinase AMP-activated catalytic subunit alpha 1 AMPK-alpha1 Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
polo like kinase 2 PLK2 Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
CDC like kinase 1 CLK1 Hs Inhibitor Inhibition 5.6 pKd 2500.0 Kd
serum/glucocorticoid regulated kinase family member 3 SGK3 Hs Inhibitor Inhibition 5.6 pKd 2500.0 Kd
G protein-coupled receptor kinase 7 GRK7 Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
maternal embryonic leucine zipper kinase MELK Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
cyclin dependent kinase 14 PFTK1 Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
RIO kinase 2 RIOK2 Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
cyclin dependent kinase 18 PCTK3 Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
platelet derived growth factor receptor alpha PDGFRA Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
spleen associated tyrosine kinase SYK Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
calcium/calmodulin dependent serine protein kinase CASK Hs Inhibitor Inhibition 5.6 pKd 2800.0 Kd
bone morphogenetic protein receptor type 2 BMPR2 Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
serine/threonine kinase 10 LOK Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
sugen kinase 110 SgK110 Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
activin A receptor type 2A ACVR2A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
activin A receptor type 2B ACVR2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 1 AKT1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 2 AKT2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 3 AKT3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 5 ASK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 6 ASK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
bone morphogenetic protein receptor type IA BMPR1A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
BR serine/threonine kinase 1 BRSK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
BR serine/threonine kinase 2 BRSK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin dependent protein kinase IV CAMK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 11B CDC2L1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 11A CDC2L2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 13 CDC2L5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 19 CDK11 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 2 CDK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 3 CDK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 5 CDK5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 8 CDK8 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase like 1 CDKL1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin-dependent kinase like 3 CDKL3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
checkpoint kinase 2 CHEK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC like kinase 3 CLK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 alpha 1 CSNK1A1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 alpha 1 like CSNK1A1L Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 delta CSNK1D Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 epsilon CSNK1E Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 gamma 1 CSNK1G1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 gamma 2 CSNK1G2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 gamma 3 CSNK1G3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase gamma DMPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 1A DYRK1A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
epidermal growth factor receptor EGFR(G719C) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
epidermal growth factor receptor EGFR(G719S) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
epidermal growth factor receptor EGFR(S752-I759del) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
EPH receptor A5 EPHA5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
EPH receptor B3 EPHB3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
erb-b2 receptor tyrosine kinase 2 ERBB2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
erb-b2 receptor tyrosine kinase 3 ERBB3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 3 ERK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 1 ERK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 4 ERK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
G protein-coupled receptor kinase 1 GRK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
glycogen synthase kinase 3 alpha GSK3A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
glycogen synthase kinase 3 beta GSK3B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
hormonally up-regulated Neu-associated kinase HUNK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
large tumor suppressor kinase 1 LATS1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
male germ cell associated kinase MAK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 1 MAP3K1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 15 MAP3K15 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK activated protein kinase 2 MAPKAPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK activated protein kinase 5 MAPKAPK5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Microtubule associated serine/threonine kinase 1 MAST1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase 6 MEK6 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET(Y1235D) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase 7 MKK7 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase alpha MRCKA Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase beta MRCKB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 4 MST1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
macrophage stimulating 1 receptor MST1R Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 3 MST2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 24 MST3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mechanistic target of rapamycin kinase MTOR Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
myosin light chain kinase 2 MYLK2 Hs Inhibitor Inhibition 5.5 pKd 3000.0 Kd
myosin IIIA MYO3A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
myosin IIIB MYO3B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Serine/threonine kinase 38 like NDR2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
nemo like kinase NLK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
oxidative stress responsive kinase 1 OSR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 14 p38-alpha Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 11 p38-beta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 13 p38-delta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 12 p38-gamma Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
p21 (RAC1) activated kinase 3 PAK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
3-phosphoinositide dependent protein kinase 1 PDPK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C2G Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(C420R) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E542K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E545A) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E545K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(H1047Y) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(I800L) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(M1043I) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(Q546K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CD Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-1 proto-oncogene, serine/threonine kinase PIM1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-2 proto-oncogene, serine/threonine kinase PIM2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-3 proto-oncogene, serine/threonine kinase PIM3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma PIP5K1C Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase, cAMP-dependent, catalytic, alpha subunit PKAC-alpha Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase, cAMP-dependent, catalytic, beta subunit PKAC-beta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase, membrane associated tyrosine/threonine 1 PKMYT1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase N2 PKN2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C delta PRKCD Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C eta PRKCH Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C iota PRKCI Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C theta PRKCQ Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase D1 PRKD1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase D2 PRKD2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase X-linked PRKX Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Raf-1 proto-oncogene, serine/threonine kinase RAF1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A4 RPS6KA4(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A6 RSK4(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 35 STK35 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
tec protein tyrosine kinase TEC Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
transforming growth factor beta receptor 1 TGFBR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
TRAF2 and NCK interacting kinase TNIK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
TRPM6 TRPM6 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
TYRO3 protein tyrosine kinase TYRO3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
VRK serine/threonine kinase 2 VRK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 32A YANK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 32B YANK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 32C YANK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
microtubule affinity regulating kinase 2 MARK2 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
mitogen-activated protein kinase kinase 2 MEK2 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
mitogen-activated protein kinase kinase kinase 11 MLK3 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
p21 (RAC1) activated kinase 1 PAK1 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
cyclin dependent kinase 16 PCTK1 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
mitogen-activated protein kinase kinase kinase 7 TAK1 Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
neurotrophic receptor tyrosine kinase 2 TRKB Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
calcium/calmodulin dependent protein kinase IG CAMK1G Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
mitogen-activated protein kinase kinase kinase 9 MLK1 Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
testis associated actin remodelling kinase 1 TESK1 Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
epidermal growth factor receptor EGFR(L858R) Hs Inhibitor Inhibition 5.5 pKd 3300.0 Kd
epidermal growth factor receptor EGFR Hs Inhibitor Inhibition 5.5 pKd 3400.0 Kd
NIMA related kinase 1 NEK1 Hs Inhibitor Inhibition 5.5 pKd 3400.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,V654A) Hs Inhibitor Inhibition 5.5 pKd 3500.0 Kd
mitogen-activated protein kinase kinase 3 MEK3 Hs Inhibitor Inhibition 5.5 pKd 3500.0 Kd
checkpoint kinase 1 CHEK1 Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
epidermal growth factor receptor EGFR(L747-T751del,Sins) Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
p21 (RAC1) activated kinase 4 PAK4 Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
Protein kinase G (PKG) 1 PRKG1 Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
zeta chain of T cell receptor associated protein kinase 70 ZAP70 Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
EPH receptor A6 EPHA6 Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
EPH receptor B2 EPHB2 Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(H1047L) Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
calcium/calmodulin dependent protein kinase kinase 2 CAMKK2 Hs Inhibitor Inhibition 5.4 pKd 4000.0 Kd
EPH receptor A4 EPHA4 Hs Inhibitor Inhibition 5.4 pKd 4000.0 Kd
mitogen-activated protein kinase kinase kinase 4 MAP3K4 Hs Inhibitor Inhibition 5.4 pKd 4100.0 Kd
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma PIP5K2C Hs Inhibitor Inhibition 5.4 pKd 4100.0 Kd
ankyrin repeat and kinase domain containing 1 ANKK1 Hs Inhibitor Inhibition 5.4 pKd 4300.0 Kd
fms related receptor tyrosine kinase 1 FLT1 Hs Inhibitor Inhibition 5.4 pKd 4300.0 Kd
aurora kinase A AURKA Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
EPH receptor A2 EPHA2 Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET(M1250T) Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
serine/threonine-protein kinase NIM1 NIM1 Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
ribosomal protein S6 kinase A5 RPS6KA5(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
protein kinase AMP-activated catalytic subunit alpha 2 AMPK-alpha2 Hs Inhibitor Inhibition 5.3 pKd 4700.0 Kd
cyclin dependent kinase 4 CDK4-cyclinD1 Hs Inhibitor Inhibition 5.3 pKd 5000.0 Kd
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites SRMS Hs Inhibitor Inhibition 5.3 pKd 5000.0 Kd
mitogen-activated protein kinase kinase 1 MEK1 Hs Inhibitor Inhibition 5.3 pKd 5100.0 Kd
kinase insert domain receptor VEGFR2 Hs Inhibitor Inhibition 5.3 pKd 5200.0 Kd
receptor interacting serine/threonine kinase 1 RIPK1 Hs Inhibitor Inhibition 5.3 pKd 5300.0 Kd
epidermal growth factor receptor EGFR(L747-S752del, P753S) Hs Inhibitor Inhibition 5.3 pKd 5600.0 Kd
epidermal growth factor receptor EGFR(L861Q) Hs Inhibitor Inhibition 5.2 pKd 5800.0 Kd
Serine/threonine kinase 38 NDR1 Hs Inhibitor Inhibition 5.2 pKd 5800.0 Kd
C-terminal Src kinase CSK Hs Inhibitor Inhibition 5.2 pKd 5900.0 Kd
p21 (RAC1) activated kinase 2 PAK2 Hs Inhibitor Inhibition 5.2 pKd 6000.0 Kd
WEE2 oocyte meiosis inhibiting kinase WEE2 Hs Inhibitor Inhibition 5.2 pKd 6000.0 Kd
receptor interacting serine/threonine kinase 2 RIPK2 Hs Inhibitor Inhibition 5.2 pKd 6100.0 Kd
epidermal growth factor receptor EGFR(E746-A750del) Hs Inhibitor Inhibition 5.2 pKd 6200.0 Kd
mitogen-activated protein kinase kinase kinase 12 DLK Hs Inhibitor Inhibition 5.2 pKd 6300.0 Kd
leukocyte receptor tyrosine kinase LTK Hs Inhibitor Inhibition 5.2 pKd 6300.0 Kd
EPH receptor A7 EPHA7 Hs Inhibitor Inhibition 5.2 pKd 6500.0 Kd
activin A receptor type 1B ACVR1B Hs Inhibitor Inhibition 5.2 pKd 6700.0 Kd
calcium/calmodulin-dependent protein kinase II beta subunit CAMK2B Hs Inhibitor Inhibition 5.2 pKd 6800.0 Kd
mitogen-activated protein kinase kinase kinase 10 MLK2 Hs Inhibitor Inhibition 5.2 pKd 6900.0 Kd
p21 (RAC1) activated kinase 6 PAK6 Hs Inhibitor Inhibition 5.2 pKd 6900.0 Kd
coenzyme Q8A ADCK3 Hs Inhibitor Inhibition 5.2 pKd 7000.0 Kd
EPH receptor A3 EPHA3 Hs Inhibitor Inhibition 5.2 pKd 7100.0 Kd
serine/threonine kinase 25 YSK1 Hs Inhibitor Inhibition 5.1 pKd 7200.0 Kd
cyclin-dependent kinase like 4 CDKL5 Hs Inhibitor Inhibition 5.1 pKd 7300.0 Kd
MAPK interacting serine/threonine kinase 1 MKNK1 Hs Inhibitor Inhibition 5.1 pKd 7300.0 Kd
serine/threonine-protein kinase MST4 MST4 Hs Inhibitor Inhibition 5.1 pKd 7500.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3CG Hs Inhibitor Inhibition 5.1 pKd 7500.0 Kd
EPH receptor A8 EPHA8 Hs Inhibitor Inhibition 5.1 pKd 7700.0 Kd
ribosomal protein S6 kinase A2 RSK3(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.1 pKd 7700.0 Kd
LIM domain kinase 2 LIMK2 Hs Inhibitor Inhibition 5.1 pKd 7900.0 Kd
large tumor suppressor kinase 2 LATS2 Hs Inhibitor Inhibition 5.1 pKd 8000.0 Kd
protein kinase C epsilon PRKCE Hs Inhibitor Inhibition 5.1 pKd 8100.0 Kd
ribosomal protein S6 kinase A3 RSK2(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.1 pKd 8100.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET Hs Inhibitor Inhibition 5.1 pKd 8500.0 Kd
cyclin dependent kinase 15 PFTAIRE2 Hs Inhibitor Inhibition 5.1 pKd 8600.0 Kd
neurotrophic receptor tyrosine kinase 3 TRKC Hs Inhibitor Inhibition 5.1 pKd 8600.0 Kd
cyclin dependent kinase 9 CDK9 Hs Inhibitor Inhibition 5.1 pKd 8800.0 Kd
misshapen like kinase 1 MINK Hs Inhibitor Inhibition 5.1 pKd 8900.0 Kd
B-Raf proto-oncogene, serine/threonine kinase BRAF(V600E) Hs Inhibitor Inhibition 5.0 pKd 9300.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 1B DYRK1B Hs Inhibitor Inhibition 5.0 pKd 9500.0 Kd
protein kinase D3 PRKD3 Hs Inhibitor Inhibition 5.0 pKd 9600.0 Kd
myosin light chain kinase 3 MLCK Hs Inhibitor Inhibition 5.0 pKd 9700.0 Kd
B-Raf proto-oncogene, serine/threonine kinase BRAF Hs Inhibitor Inhibition 5.0 pKd 9800.0 Kd
receptor interacting serine/threonine kinase 4 RIPK4 Hs Inhibitor Inhibition 5.0 pKd 9800.0 Kd
mitogen-activated protein kinase kinase 4 MEK4 Hs Inhibitor Inhibition 5.0 pKd 9900.0 Kd

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]