Download information on nuclear receptors as part of our target list in CSV format
0B. DAX-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
0B. DAX-like receptors | NR0B1 | DAX1 |
NR0B1 |
Nr0b1 |
Nr0b1 |
Orphan | |
0B. DAX-like receptors | NR0B2 | SHP |
NR0B2 |
Nr0b2 |
Nr0b2 |
Orphan | |
1A. Thyroid hormone receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1A. Thyroid hormone receptors |
T4
triiodothyronine |
NR1A1 | Thyroid hormone receptor-α |
THRA |
Thra |
Thra |
Triiodothyronine is the more potent endogenous ligand |
1A. Thyroid hormone receptors |
T4
triiodothyronine |
NR1A2 | Thyroid hormone receptor-β |
THRB |
Thrb |
Thrb |
Triiodothyronine is the more potent endogenous ligand |
1B. Retinoic acid receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1B. Retinoic acid receptors |
tretinoin
|
NR1B1 | Retinoic acid receptor-α |
RARA |
Rara |
Rara |
|
1B. Retinoic acid receptors |
tretinoin
|
NR1B2 | Retinoic acid receptor-β |
RARB |
Rarb |
Rarb |
|
1B. Retinoic acid receptors |
tretinoin
|
NR1B3 | Retinoic acid receptor-γ |
RARG |
Rarg |
Rarg |
|
1C. Peroxisome proliferator-activated receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1C. Peroxisome proliferator-activated receptors |
LTB4
pristanic acid 8S-HETE |
NR1C1 | Peroxisome proliferator-activated receptor-α |
PPARA |
Ppara |
Ppara |
LTB4, fatty acids and eisosanoids are natural ligands |
1C. Peroxisome proliferator-activated receptors |
tretinoin
|
NR1C2 | Peroxisome proliferator-activated receptor-β/δ |
PPARD |
Ppard |
Ppard |
Fatty acids and eisosanoids are natural ligands |
1C. Peroxisome proliferator-activated receptors |
15-deoxy-Δ-12,14-prostaglandin J2
linoleic acid |
NR1C3 | Peroxisome proliferator-activated receptor-γ |
PPARG |
Pparg |
Pparg |
Fatty acids, prostaglandin J2 and eisosanoids are reported natural ligands |
1D. Rev-Erb receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1D. Rev-Erb receptors |
heme
|
NR1D1 | Rev-Erb-α |
NR1D1 |
Nr1d1 |
Nr1d1 |
Orphan |
1D. Rev-Erb receptors |
heme
|
NR1D2 | Rev-Erb-β |
NR1D2 |
Nr1d2 |
Nr1d2 |
Orphan |
1F. Retinoic acid-related orphans | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1F. Retinoic acid-related orphans |
cholesterol
|
NR1F1 | RAR-related orphan receptor-α |
RORA |
Rora |
Rora |
|
1F. Retinoic acid-related orphans |
tretinoin
|
NR1F2 | RAR-related orphan receptor-β |
RORB |
Rorb |
Rorb |
|
1F. Retinoic acid-related orphans |
25-hydroxycholesterol
|
NR1F3 | RAR-related orphan receptor-γ |
RORC |
Rorc |
Rorc |
Orphan |
1H. Liver X receptor-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1H. Liver X receptor-like receptors |
chenodeoxycholic acid
cholic acid deoxycholic acid lithocholic acid 22R-hydroxycholesterol |
NR1H4 | Farnesoid X receptor |
NR1H4 |
Nr1h4 |
Nr1h4 |
A series of bile acids are natural ligands |
1H. Liver X receptor-like receptors |
cholesten
desmosterol lanosterol vitamin D3 |
NR1H5 | Farnesoid X receptor-β |
NR1H5P |
Nr1h5 |
Nr1h5 |
A series of oxysterols and bile acids are natural ligands |
1H. Liver X receptor-like receptors |
24(S), 25-epoxycholesterol
24(S)-hydroxycholesterol 27-hydroxycholesterol 22R-hydroxycholesterol |
NR1H3 | Liver X receptor-α |
NR1H3 |
Nr1h3 |
Nr1h3 |
A series of oxysterols are natural ligands |
1H. Liver X receptor-like receptors |
24(S), 25-epoxycholesterol
24(S)-hydroxycholesterol 27-hydroxycholesterol 22R-hydroxycholesterol |
NR1H2 | Liver X receptor-β |
NR1H2 |
Nr1h2 |
Nr1h2 |
A series of oxysterols are natural ligands |
1I. Vitamin D receptor-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
1I. Vitamin D receptor-like receptors |
calcitriol-26,23-lactone
1,25-dihydroxyvitamin D3 3-keto-lithocholic acid lithocholic acid |
NR1I1 | Vitamin D receptor |
VDR |
Vdr |
Vdr |
|
1I. Vitamin D receptor-like receptors |
17β-estradiol
3-keto-lithocholic acid lithocholic acid |
NR1I2 | Pregnane X receptor |
NR1I2 |
Nr1i2 |
Nr1i2 |
Xenobiotics, steroids and benzoates have been proposed as the natural ligands |
1I. Vitamin D receptor-like receptors | NR1I3 | Constitutive androstane receptor |
NR1I3 |
Nr1i3 |
Nr1i3 |
Xenobiotics and androstanes have been proposed as the natural ligands | |
2A. Hepatocyte nuclear factor-4 receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
2A. Hepatocyte nuclear factor-4 receptors |
linoleic acid
|
NR2A1 | Hepatocyte nuclear factor-4-α |
HNF4A |
Hnf4a |
Hnf4a |
Orphan |
2A. Hepatocyte nuclear factor-4 receptors | NR2A2 | Hepatocyte nuclear factor-4-γ |
HNF4G |
Hnf4g |
Hnf4g |
Orphan | |
2B. Retinoid X receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
2B. Retinoid X receptors |
alitretinoin
docosahexaenoic acid |
NR2B1 | Retinoid X receptor-α |
RXRA |
Rxra |
Rxra |
|
2B. Retinoid X receptors |
alitretinoin
|
NR2B2 | Retinoid X receptor-β |
RXRB |
Rxrb |
Rxrb |
|
2B. Retinoid X receptors |
alitretinoin
|
NR2B3 | Retinoid X receptor-γ |
RXRG |
Rxrg |
Rxrg |
|
2C. Testicular receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
2C. Testicular receptors | NR2C1 | Testicular receptor 2 |
NR2C1 |
Nr2c1 |
Nr2c1 |
Orphan | |
2C. Testicular receptors |
retinol
tretinoin |
NR2C2 | Testicular receptor 4 |
NR2C2 |
Nr2c2 |
Nr2c2 |
Orphan |
2E. Tailless-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
2E. Tailless-like receptors | NR2E1 | TLX |
NR2E1 |
Nr2e1 |
Nr2e1 |
Orphan | |
2E. Tailless-like receptors | NR2E3 | PNR |
NR2E3 |
Nr2e3 |
Orphan | ||
2F. COUP-TF-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
2F. COUP-TF-like receptors | NR2F1 | COUP-TF1 |
NR2F1 |
Nr2f1 |
Nr2f1 |
Orphan | |
2F. COUP-TF-like receptors | NR2F2 | COUP-TF2 |
NR2F2 |
Nr2f2 |
Nr2f2 |
Orphan | |
2F. COUP-TF-like receptors | NR2F6 | V-erbA-related gene |
NR2F6 |
Nr2f6 |
Nr2f6 |
Orphan | |
3A. Estrogen receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
3A. Estrogen receptors |
17β-estradiol
estriol estrone |
NR3A1 | Estrogen receptor-α |
ESR1 |
Esr1 |
Esr1 |
|
3A. Estrogen receptors |
17β-estradiol
estrone |
NR3A2 | Estrogen receptor-β |
ESR2 |
Esr2 |
Esr2 |
|
3B. Estrogen-related receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
3B. Estrogen-related receptors | NR3B1 | Estrogen-related receptor-α |
ESRRA |
Esrra |
Esrra |
Orphan | |
3B. Estrogen-related receptors | NR3B2 | Estrogen-related receptor-β |
ESRRB |
Esrrb |
Esrrb |
Orphan | |
3B. Estrogen-related receptors | NR3B3 | Estrogen-related receptor-γ |
ESRRG |
Esrrg |
Esrrg |
Orphan | |
3C. 3-Ketosteroid receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
3C. 3-Ketosteroid receptors |
dihydrotestosterone
testosterone |
NR3C4 | Androgen receptor |
AR |
Ar |
Ar |
Dihydrotestosterone has greater potency than testosterone |
3C. 3-Ketosteroid receptors |
aldosterone
corticosterone cortisol deoxycorticosterone deoxycortisone |
NR3C1 | Glucocorticoid receptor |
NR3C1 |
Nr3c1 |
Nr3c1 |
Cortisol and corticosterone are the principal endogenous agonists |
3C. 3-Ketosteroid receptors |
aldosterone
corticosterone cortisol deoxycorticosterone progesterone |
NR3C2 | Mineralocorticoid receptor |
NR3C2 |
Nr3c2 |
Nr3c2 |
|
3C. 3-Ketosteroid receptors |
progesterone
|
NR3C3 | Progesterone receptor |
PGR |
Pgr |
Pgr |
|
4A. Nerve growth factor IB-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
4A. Nerve growth factor IB-like receptors | NR4A1 | Nerve Growth factor IB |
NR4A1 |
Nr4a1 |
Nr4a1 |
Orphan | |
4A. Nerve growth factor IB-like receptors | NR4A2 | Nuclear receptor related 1 |
NR4A2 |
Nr4a2 |
Nr4a2 |
Orphan | |
4A. Nerve growth factor IB-like receptors | NR4A3 | Neuron-derived orphan receptor 1 |
NR4A3 |
Nr4a3 |
Nr4a3 |
Orphan | |
5A. Fushi tarazu F1-like receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
5A. Fushi tarazu F1-like receptors | NR5A1 | Steroidogenic factor 1 |
NR5A1 |
Nr5a1 |
Nr5a1 |
Orphan | |
5A. Fushi tarazu F1-like receptors | NR5A2 | Liver receptor homolog-1 |
NR5A2 |
Nr5a2 |
Nr5a2 |
Orphan | |
6A. Germ cell nuclear factor receptors | |||||||
Family name | Ligand | Receptor nomenclature | Receptor common name | Human gene symbol | Rat gene symbol | Mouse gene symbol | Comment |
6A. Germ cell nuclear factor receptors | NR6A1 | Germ cell nuclear factor |
NR6A1 |
Nr6a1 |
Nr6a1 |
Orphan |