Quaternary Structure: Complexes

Bone morphogenetic protein receptors

Growth/differentiation factor receptors

Activin receptors

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	513	2q22.3-q23.1	ACVR2A	activin A receptor type 2A
Mouse	1	513	2 28.38 cM	Acvr2a	activin receptor IIA
Rat	1	513	3q12	Acvr2a	activin A receptor type 2A

Previous and Unofficial Names

activin A receptor, type II | activin receptor IIA | ActRIIa | activin receptor 2A | ACVR2 | activin A receptor type IIA

Database Links
Alphafold	P27037 (Hs), P27038 (Mm), P38444 (Rn)
BRENDA	2.7.11.30
ChEMBL Target	CHEMBL5616 (Hs)
Ensembl Gene	ENSG00000121989 (Hs), ENSMUSG00000052155 (Mm), ENSRNOG00000005334 (Rn)
Entrez Gene	92 (Hs), 11480 (Mm), 29263 (Rn)
Human Protein Atlas	ENSG00000121989 (Hs)
KEGG Enzyme	2.7.11.30
KEGG Gene	hsa:92 (Hs), mmu:11480 (Mm), rno:29263 (Rn)
OMIM	102581 (Hs)
Pharos	P27037 (Hs)
RefSeq Nucleotide	NM_001616 (Hs), NM_007396 (Mm), NM_031571 (Rn)
RefSeq Protein	NP_001607 (Hs), NP_031422 (Mm), NP_113759 (Rn)
UniProtKB	P27037 (Hs), P27038 (Mm), P38444 (Rn)
Wikipedia	ACVR2A (Hs)

Selected 3D Structures
	Description:  Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin PDB Id:  3Q4T Ligand:  dorsomorphin Resolution:  1.96Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.11.30

Natural/Endogenous Ligands
myostatin {Sp: Human}
Comments: Endogenous ligands may include growth/differentiation factor-6 [1].

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference bimagrumab Hs Binding 9.4 pKd 2 ⤷ pKd 9.4 (Kd 4.34x10-10 M) [2] Description: Binding affinity of clone MOR08159

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 3-4
Key to terms and symbols		Click column headers to sort
Target used in screen: ACVR2A
Ligand Sp. Type Action Value Parameter PD-173955 Hs Inhibitor Inhibition 8.0 pKd PP-242 Hs Inhibitor Inhibition 7.7 pKd dasatinib Hs Inhibitor Inhibition 6.7 pKd KW-2449 Hs Inhibitor Inhibition 6.5 pKd NVP-TAE684 Hs Inhibitor Inhibition 5.7 pKd lestaurtinib Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd linifanib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »