Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	488	20q13.33	SRMS	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Mouse	-	496	2 103.62 cM	Srms	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Rat	-	507	3 q43	Srms	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

Previous and Unofficial Names

SRM

Database Links
Alphafold	Q9H3Y6 (Hs), Q62270 (Mm)
BRENDA	2.7.10.2
CATH/Gene3D	3.30.505.10
ChEMBL Target	CHEMBL5703 (Hs)
Ensembl Gene	ENSG00000125508 (Hs), ENSMUSG00000027579 (Mm), ENSRNOG00000013003 (Rn)
Entrez Gene	6725 (Hs), 20811 (Mm), 296472 (Rn)
Human Protein Atlas	ENSG00000125508 (Hs)
KEGG Enzyme	2.7.10.2
KEGG Gene	hsa:6725 (Hs), mmu:20811 (Mm), rno:296472 (Rn)
Pharos	Q9H3Y6 (Hs)
RefSeq Nucleotide	NM_080823 (Hs), NM_011481 (Mm), NM_001011961 (Rn)
RefSeq Protein	NP_543013 (Hs), NP_035611 (Mm), NP_001011961 (Rn)
UniProtKB	Q9H3Y6 (Hs), Q62270 (Mm)
Wikipedia	SRMS (Hs)

Enzyme Reaction
EC Number: 2.7.10.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 66 [PMID: 21802293] Hs Inhibition - - 3 ⤷ [3] Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
SRMS activity is inhibited by 98% in the presence of 1μM compound 66 [PMID 21802293] [3].

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: SRMS
Ligand Sp. Type Action Value Parameter dasatinib Hs Inhibitor Inhibition 7.9 pKd foretinib Hs Inhibitor Inhibition 7.7 pKd PLX-4720 Hs Inhibitor Inhibition 7.7 pKd SU-14813 Hs Inhibitor Inhibition 7.2 pKd AST-487 Hs Inhibitor Inhibition 7.1 pKd bosutinib Hs Inhibitor Inhibition 7.0 pKd NVP-TAE684 Hs Inhibitor Inhibition 6.8 pKd Ki-20227 Hs Inhibitor Inhibition 6.4 pKd PD-173955 Hs Inhibitor Inhibition 6.2 pKd tamatinib Hs Inhibitor Inhibition 6.2 pKd
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EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/SRMS
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 6.3 Lck inhibitor Hs Inhibitor Inhibition 14.2 dasatinib Hs Inhibitor Inhibition 17.0 Src kinase inhibitor I Hs Inhibitor Inhibition 31.6 alsterpaullone 2-cyanoethyl Hs Inhibitor Inhibition 78.6 bohemine Hs Inhibitor Inhibition 82.0 bisindolylmaleimide IV Hs Inhibitor Inhibition 82.4 Cdk4 inhibitor III Hs Inhibitor Inhibition 82.4 Chk2 inhibitor II Hs Inhibitor Inhibition 83.1 Cdk4 inhibitor II Hs Inhibitor Inhibition 83.5
Displaying the top 10 most potent ligands  View all ligands in screen »